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Associates of bone mineral density in older African Americans.
Tuesday,2012-11-06 12:07 America/Los_Angeles — eenright
| Title | Associates of bone mineral density in older African Americans. |
| Publication Type | Journal Article |
| Year of Publication | 2004 |
| Authors | Robbins, J, Hirsch, C, Cauley, J |
| Journal | J Natl Med Assoc |
| Volume | 96 |
| Issue | 12 |
| Pagination | 1609-15 |
| Date Published | 2004 Dec |
| ISSN | 0027-9684 |
| Keywords | Aged, Body Weight, Bone Density, Cross-Sectional Studies, Female, Humans, Male, Osteoporosis, Risk Factors |
| Abstract | <p><b>OBJECTIVES: </b>To assess correlates of bone mineral density (BMD) in older African Americans.</p><p><b>PARTICIPANTS: </b>189 women and 115 men over age 64.</p><p><b>METHODS: </b>Variables investigated: BMD by dual X-ray absorptiometry (DXA), medications, cardiovascular disease risk factors, demographic, lifestyle factors and functional status. Variables showing univariate correlation with BMD (p < or = 0.1) were entered into sex-stratified linear regression models.</p><p><b>RESULTS: </b>Age range 67-96 (mean 75). The mean BMD (gm/ cm2 +/- standard deviation) is reported for three sites. Total body: 1.03 (+/- 0.12) in women, 1.21 (+/- 0.11) in men. Spine: 1.05 (+/- 0.24) in women, 1.22 (+/- 0.26) in men. Total hip: 0.85 (+/- 0.15) in women, 1.04 (+/- 0.17) in men. Gender was significantly associated with BMD (t-test, p < 0.001). The R2 for tested variables were highly significant only for weight. Age was only significant for total hip in women (p < 0.05). Each kilogram of weight change was associated with a 5.3-6.8 mg/cm2 change in BMD.</p><p><b>CONCLUSIONS: </b>In a population-based cohort of older African Americans, average BMD was significantly greater in men than women. Weight accounted for most of the explained variability (R2) in BMD; age added little to the overall R2. Lower-weight, older African-American men and women are at significantly increased risk for low BMD and, thus, likely to be at greater risk for osteoporotic fracture.</p> |
| Alternate Journal | J Natl Med Assoc |
| PubMed ID | 15622691 |
| PubMed Central ID | PMC2568675 |
| Grant List | N01-HC-85079 / HC / NHLBI NIH HHS / United States N01-HC-85086 / HC / NHLBI NIH HHS / United States RC-HL 15103 / RC / CCR NIH HHS / United States |