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Subclinical brain magnetic resonance imaging abnormalities predict physical functional decline in high-functioning older adults.
Tuesday,2012-11-06 12:07 America/Los_Angeles — eenright
| Title | Subclinical brain magnetic resonance imaging abnormalities predict physical functional decline in high-functioning older adults. |
| Publication Type | Journal Article |
| Year of Publication | 2005 |
| Authors | Rosano, C, Kuller, LH, Chung, H, Arnold, AM, Longstreth, WT, Newman, AB |
| Journal | J Am Geriatr Soc |
| Volume | 53 |
| Issue | 4 |
| Pagination | 649-54 |
| Date Published | 2005 Apr |
| ISSN | 0002-8614 |
| Keywords | Activities of Daily Living, Aged, Aged, 80 and over, Brain, Female, Follow-Up Studies, Gait, Humans, Incidence, Magnetic Resonance Imaging, Male, Proportional Hazards Models, Psychomotor Disorders, Risk Factors, United States |
| Abstract | <p><b>OBJECTIVES: </b>To determine whether severity of subclinical brain magnetic resonance imaging (MRI) abnormalities predicts incident self-reported physical impairment or rate of decline in motor performance.</p><p><b>DESIGN: </b>Longitudinal analysis, average follow-up time: 4.0 years.</p><p><b>SETTING: </b>Cardiovascular Health Study (CHS).</p><p><b>PARTICIPANTS: </b>CHS participants with modified Mini-Mental State Examination (3MS) score of 80 or greater, no self-reported disability, no history of stroke, and at least one assessment of mobility (n=2,450, mean age=74.4).</p><p><b>MEASUREMENTS: </b>Brain MRI abnormalities (ventricular enlargement, white matter hyperintensities, subcortical and basal ganglia small brain infarcts), self-reported physical impairment (difficulty walking half a mile or with one or more activities of daily living), and motor performance (gait speed, timed chair stand).</p><p><b>RESULTS: </b>After adjusting for demographics, cardiovascular risk factors, and diseases, risk of incident self-reported physical impairment was 35% greater for those with severe ventricular enlargement than for those with minimal ventricular enlargement, 22% greater for those with moderate white matter hyperintensities than for those with minimal white matter hyperintensities, and 26% greater for participants with at least one brain infarct than for those with no infarcts. Those with moderate to severe brain abnormalities experienced faster gait speed decline (0.02 m/s per year) than those with no MRI abnormalities (0.01 m/s per year). Further adjustment for incident stroke, incident dementia, and 3MS score did not substantially attenuate hazard ratios for incident self-reported physical impairment or coefficients for decline in gait speed.</p><p><b>CONCLUSION: </b>Subclinical structural brain abnormalities in high-functioning older adults can increase the risk of developing physical disabilities and declining in motor performance.</p> |
| DOI | 10.1111/j.1532-5415.2005.53214.x |
| Alternate Journal | J Am Geriatr Soc |
| PubMed ID | 15817012 |
| Grant List | N01 HC 15103 / HC / NHLBI NIH HHS / United States N01 HC 35129 / HC / NHLBI NIH HHS / United States N01 HC 85079 / HC / NHLBI NIH HHS / United States N01 HC 85080 / HC / NHLBI NIH HHS / United States N01 HC 85081 / HC / NHLBI NIH HHS / United States N01 HC 85082 / HC / NHLBI NIH HHS / United States N01 HC 85083 / HC / NHLBI NIH HHS / United States N01 HC 85084 / HC / NHLBI NIH HHS / United States N01 HC 85085 / HC / NHLBI NIH HHS / United States N01 HC 85086 / HC / NHLBI NIH HHS / United States T32 AG 00181-11 / AG / NIA NIH HHS / United States |