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Soluble CD14 and Risk of Heart Failure and Its Subtypes in Older Adults.
Tuesday,2020-08-04 17:53 America/Los_Angeles — ecterry
| Title | Soluble CD14 and Risk of Heart Failure and Its Subtypes in Older Adults. |
| Publication Type | Journal Article |
| Year of Publication | 2020 |
| Authors | Al-Kindi, SG, Bůzková, P, Shitole, SG, Reiner, AP, Garg, PK, Gottdiener, JS, Psaty, BM, Kizer, JR |
| Journal | J Card Fail |
| Volume | 26 |
| Issue | 5 |
| Pagination | 410-419 |
| Date Published | 2020 May |
| ISSN | 1532-8414 |
| Abstract | <p><b>BACKGROUND: </b>CD14 is a membrane glycoprotein primarily expressed by myeloid cells that plays a key role in inflammation. Soluble CD14 (sCD14) levels carry a poor prognosis in chronic heart failure (HF), but whether elevations in sCD14 precede HF is unknown. We tested the hypothesis that sCD14 is associated with HF incidence and its subtypes independent of major inflammatory biomarkers among older adults.</p><p><b>METHODS AND RESULTS: </b>We included participants in the Cardiovascular Health Study without preexisting HF and available baseline sCD14. We evaluated the associations of sCD14, high-sensitivity C-reactive protein (hsCRP), interleukin (IL)-6, and white blood cell count (WBC) with incident HF and subtypes using Cox regression. Among 5217 participants, 1878 had incident HF over 13.6 years (609 classifiable as HF with preserved ejection fraction [HFpEF] and 419 as HF with reduced ejection fraction [HFrEF]). After adjusting for clinical and laboratory covariates, sCD14 was significantly associated with incident HF (hazard ratio [HR]: 1.56 per doubling, 95% confidence interval [CI]: 1.29-1.89), an association that was numerically stronger than for hsCRP (HR per doubling: 1.10, 95% CI: 1.06-1.15), IL-6 (HR: 1.18, 95% CI: 1.10-1.25), and WBC (HR: 1.24, 95% CI: 1.09-1.42), and that remained significant after adjustment for the other markers of inflammation. This association for sCD14 was observed with HFpEF (HR: 1.50, 95% CI: 1.07-2.10) but not HFrEF (HR: 0.99, 95% CI: 0.67-1.49).</p><p><b>CONCLUSIONS: </b>Plasma sCD14 was associated with incident HF independently and numerically more strongly than other major inflammatory markers. This association was only observed with HFpEF in the subset with classifiable HF subtypes. Pending replication, these findings have potentially important therapeutic implications.</p> |
| DOI | 10.1016/j.cardfail.2020.03.003 |
| Alternate Journal | J. Card. Fail. |
| PubMed ID | 32165348 |
| PubMed Central ID | PMC7245550 |
| Grant List | U01 HL080295 / HL / NHLBI NIH HHS / United States U01 HL130114 / HL / NHLBI NIH HHS / United States HHSN268200800007C / HL / NHLBI NIH HHS / United States N01HC85086 / HL / NHLBI NIH HHS / United States HHSN268201200036C / HL / NHLBI NIH HHS / United States N01HC85082 / HL / NHLBI NIH HHS / United States N01HC85083 / HL / NHLBI NIH HHS / United States K24 HL135413 / HL / NHLBI NIH HHS / United States N01HC85080 / HL / NHLBI NIH HHS / United States N01HC85081 / HL / NHLBI NIH HHS / United States N01HC85079 / HL / NHLBI NIH HHS / United States R01 AG023629 / AG / NIA NIH HHS / United States |
ePub date:
10/05