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Determinants of vascular dementia in the Cardiovascular Health Cognition Study.
Tuesday,2012-11-06 12:07 America/Los_Angeles — eenright
| Title | Determinants of vascular dementia in the Cardiovascular Health Cognition Study. |
| Publication Type | Journal Article |
| Year of Publication | 2005 |
| Authors | Kuller, LH, Lopez, OL, Jagust, WJ, Becker, JT, DeKosky, ST, Lyketsos, C, Kawas, C, Breitner, JCS, Fitzpatrick, A, Dulberg, C |
| Journal | Neurology |
| Volume | 64 |
| Issue | 9 |
| Pagination | 1548-52 |
| Date Published | 2005 May 10 |
| ISSN | 1526-632X |
| Keywords | Age Factors, Aged, Aged, 80 and over, Alzheimer Disease, Atrophy, Brain, Cardiovascular Diseases, Cerebral Arteries, Cerebral Infarction, Cohort Studies, Comorbidity, Continental Population Groups, Dementia, Vascular, Female, Humans, Lateral Ventricles, Magnetic Resonance Imaging, Male, Nerve Fibers, Myelinated, Neuropsychological Tests, Risk Factors, Sex Factors |
| Abstract | <p><b>OBJECTIVE: </b>The authors evaluated 3,375 participants without dementia at the time of MRI in 1991 to 1994 over 5.7 years for incident dementia and type of dementia.</p><p><b>METHODS: </b>Incidence of and risk factors for vascular dementia (VaD) were measured using both pre-MRI and modified State of California Alzheimer's Disease Diagnostic and Treatment Centers (ADDTC) post-MRI review and further classified Alzheimer disease (AD) by the National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer's Disease and Related Disorders Association (NINCDS-ADRDA) criteria.</p><p><b>RESULTS: </b>Approximately 44% (213) of 480 incident dementia cases were classified as possible or probable VaD by ADDTC. The incidence of VaD increased with age and was greater in blacks than whites. Risk factors for VaD included age, Modified Mini-Mental State Examination, high white matter grade, number of MRI infarcts, ventricular size, and history of stroke.</p><p><b>CONCLUSIONS: </b>Vascular disease in the brain is prevalent among incident dementia cases. There is a substantial overlap between cases classified as Alzheimer disease by Neurological and Communicative Disorders and Stroke and the Alzheimer's Disease and Related Disorders Association and vascular dementia (VaD) by modified State of California Alzheimer's Disease Diagnostic and Treatment Centers criteria. The substantial contribution of vascular disease would be missed without inclusion of MRI. Treatment of risk factors for VaD could have an important impact on incidence of dementia.</p> |
| DOI | 10.1212/01.WNL.0000160115.55756.DE |
| Alternate Journal | Neurology |
| PubMed ID | 15883315 |
| PubMed Central ID | PMC3378359 |
| Grant List | R01 AG021055 / AG / NIA NIH HHS / United States AG15928 / AG / NIA NIH HHS / United States N01-HC-85085 / HC / NHLBI NIH HHS / United States R01 AG015928 / AG / NIA NIH HHS / United States N01-HC-85081 / HC / NHLBI NIH HHS / United States N01 HC015103 / HC / NHLBI NIH HHS / United States N01-HC-85086 / HC / NHLBI NIH HHS / United States N01HC85086 / HL / NHLBI NIH HHS / United States N01-HC-85082 / HC / NHLBI NIH HHS / United States N01-HC-85083 / HC / NHLBI NIH HHS / United States N01-HC-85079 / HC / NHLBI NIH HHS / United States N01HC85079 / HL / NHLBI NIH HHS / United States N01 HC035129 / HC / NHLBI NIH HHS / United States N01-HC-85084 / HC / NHLBI NIH HHS / United States |