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Alcohol use and risk of ischemic stroke among older adults: the cardiovascular health study.
Tuesday,2012-11-06 12:07 America/Los_Angeles — eenright
| Title | Alcohol use and risk of ischemic stroke among older adults: the cardiovascular health study. |
| Publication Type | Journal Article |
| Year of Publication | 2005 |
| Authors | Mukamal, KJ, Chung, H, Jenny, NS, Kuller, LH, Longstreth, WT, Mittleman, MA, Burke, GL, Cushman, M, Beauchamp, NJ, Siscovick, DS |
| Journal | Stroke |
| Volume | 36 |
| Issue | 9 |
| Pagination | 1830-4 |
| Date Published | 2005 Sep |
| ISSN | 1524-4628 |
| Keywords | Aged, Alcohol Drinking, Apolipoproteins E, Brain Infarction, Brain Ischemia, Cohort Studies, Female, Follow-Up Studies, Genetic Predisposition to Disease, Genotype, Humans, Hypertension, Inflammation, Ischemia, Lipids, Male, Middle Aged, Multivariate Analysis, Myocardial Infarction, Prospective Studies, Risk, Risk Factors, Stroke, Substance-Related Disorders, Thrombosis, Time Factors, Vascular Diseases |
| Abstract | <p><b>BACKGROUND AND PURPOSE: </b>The association of light to moderate alcohol consumption with risk of ischemic stroke remains uncertain, as are the roles of potentially mediating factors and modification by apolipoprotein E (apoE) genotype.</p><p><b>METHODS: </b>We studied the prospective association of alcohol consumption and risk of ischemic stroke among 4410 participants free of cardiovascular disease at baseline in the Cardiovascular Health Study, a population-based cohort study of older adults from 4 US communities. Participants reported their consumption of alcoholic beverages yearly.</p><p><b>RESULTS: </b>During an average follow-up period of 9.2 years, 434 cases of incident ischemic stroke occurred. Compared with long-term abstainers, the multivariate relative risks of ischemic stroke were 0.85 (95% CI, 0.63 to 1.13), 0.75 (95% CI, 0.53 to 1.06), 0.82 (95% CI, 0.51 to 1.30), and 1.03 (95% CI, 0.68 to 1.57) among consumers of <1, 1 to 6, 7 to 13, and > or =14 drinks per week (P quadratic trend 0.06). ApoE genotype appeared to modify the alcohol-ischemic stroke relationship (P interaction 0.08), with generally lower risks among drinkers than abstainers in apoE4-negative participants but higher risks among drinkers than abstainers among apoE4-positive participants. We could not identify candidate mediators among lipid, inflammatory, and prothrombotic factors.</p><p><b>CONCLUSIONS: </b>In this study of older adults, the association of alcohol use and risk of ischemic stroke was U-shaped, with modestly lower risk among consumers of 1 to 6 drinks per week. However, apoE genotype may modify this association, and even moderate alcohol intake may be associated with an increased risk of ischemic stroke among apoE4-positive older adults.</p> |
| DOI | 10.1161/01.STR.0000177587.76846.89 |
| Alternate Journal | Stroke |
| PubMed ID | 16081863 |
| Grant List | N01 HC-15103 / HC / NHLBI NIH HHS / United States N01-HC-85079 / HC / NHLBI NIH HHS / United States N01-HC-85086 / HC / NHLBI NIH HHS / United States |