You are here
Risk factors for declining ankle-brachial index in men and women 65 years or older: the Cardiovascular Health Study.
Tuesday,2012-11-06 12:07 America/Los_Angeles — eenright
| Title | Risk factors for declining ankle-brachial index in men and women 65 years or older: the Cardiovascular Health Study. |
| Publication Type | Journal Article |
| Year of Publication | 2005 |
| Authors | Kennedy, M, Solomon, C, Manolio, TA, Criqui, MH, Newman, AB, Polak, JF, Burke, GL, Enright, P, Cushman, M |
| Journal | Arch Intern Med |
| Volume | 165 |
| Issue | 16 |
| Pagination | 1896-902 |
| Date Published | 2005 Sep 12 |
| ISSN | 0003-9926 |
| Keywords | Aged, Aged, 80 and over, Ankle, Brachial Artery, Cardiovascular Diseases, Female, Humans, Male, Peripheral Vascular Diseases, Risk Assessment, Risk Factors |
| Abstract | <p><b>BACKGROUND: </b>An ankle-brachial index (ABI) of less than 0.9 is a noninvasive measure of lower extremity arterial disease and a predictor of cardiovascular events. Little information is available on longitudinal change in ABI or on risk factors for declining ABI in a community-based population.</p><p><b>METHODS: </b>To assess risk factors for ABI decline, we studied 5888 participants in the Cardiovascular Health Study cohort (men and women 65 years or older). We measured ABI in 1992-1993 and again in 1998-1999. At baseline, we excluded individuals with an ABI less than 0.9, ABI greater than 1.4, or confirmed symptomatic lower extremity arterial disease (n = 823). The group with ABI decline included 218 participants with decline greater than 0.15 and to 0.9 or less. The comparison group comprised the remaining 2071 participants with follow-up ABI.</p><p><b>RESULTS: </b>The percentage of participants with ABI decline was 9.5% over 6 years of follow-up. The mean +/- SD decline was 0.33 +/- 0.12 in cases of ABI decline and 0.02 +/- 0.13 in non-cases. Independent predictors of ABI decline, reported as odds ratios, were age, 1.96 (95% confidence interval [CI], 1.42-2.71) for 75 to 84 years and 3.79 (95% CI, 1.36-10.5) for those older than 85 years compared with those younger than 75 years; current cigarette use, 1.74 (95% CI, 1.02-2.96); hypertension, 1.64 (95% CI, 1.18-2.28); diabetes, 1.77 (95% CI, 1.14-2.76); higher low-density lipoprotein cholesterol level, 1.60 (95% CI, 1.03-2.51), and lipid-lowering drug use 1.74 (95% CI, 1.05-2.89).</p><p><b>CONCLUSION: </b>Worsening lower extremity arterial disease, assessed as ABI decline, occurred in 9.5% of this elderly cohort over 6 years and was associated with modifiable vascular disease risk factors.</p> |
| DOI | 10.1001/archinte.165.16.1896 |
| Alternate Journal | Arch Intern Med |
| PubMed ID | 16157835 |
| Grant List | 01-HC-35129 / HC / NHLBI NIH HHS / United States HL-03618 / HL / NHLBI NIH HHS / United States N01-HC-15103 / HC / NHLBI NIH HHS / United States N01-HC-85079 / HC / NHLBI NIH HHS / United States N01-HC-85080 / HC / NHLBI NIH HHS / United States N01-HC-85081 / HC / NHLBI NIH HHS / United States N01-HC-85082 / HC / NHLBI NIH HHS / United States N01-HC-85083 / HC / NHLBI NIH HHS / United States N01-HC-85084 / HC / NHLBI NIH HHS / United States N01-HC-85085 / HC / NHLBI NIH HHS / United States N01-HC-85086 / HC / NHLBI NIH HHS / United States T32 HL 07594 / HL / NHLBI NIH HHS / United States |