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Rooted in risk: genetic predisposition for low-density lipoprotein cholesterol level associates with diminished low-density lipoprotein cholesterol response to statin treatment.

TitleRooted in risk: genetic predisposition for low-density lipoprotein cholesterol level associates with diminished low-density lipoprotein cholesterol response to statin treatment.
Publication TypeJournal Article
Year of Publication2016
AuthorsSmit, RAj, Postmus, I, Trompet, S, Barnes, MR, Warren, H, Arsenault, BJ, Chasman, DI, Cupples, AL, Hitman, GA, Krauss, RM, Li, X, Psaty, BM, Stein, CM, Rotter, JI, J Jukema, W
JournalPharmacogenomics
Volume17
Issue15
Pagination1621-1628
Date Published2016 10
ISSN1744-8042
KeywordsCholesterol, LDL, Genetic Predisposition to Disease, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Pharmacogenetics, Polymorphism, Single Nucleotide, Triglycerides
Abstract<p><b>AIMS: </b>To utilize previously reported lead SNPs for low-density lipoprotein cholesterol (LDL-c) levels to find additional loci of importance to statin response, and examine whether genetic predisposition to LDL-c levels associates with differential statin response.</p><p><b>METHODS: </b>We investigated effects on statin response of 59 LDL-c SNPs, by combining summary level statistics from the Global Lipids Genetics and Genomic Investigation of Statin Therapy consortia.</p><p><b>RESULTS: </b>Lead SNPs for APOE, SORT1 and NPC1L1 were associated with a decreased LDL-c response to statin treatment, as was overall genetic predisposition for increased LDL-c levels as quantified with 59 SNPs, with a 5.4% smaller statin response per standard deviation increase in genetically raised LDL-c levels.</p><p><b>CONCLUSION: </b>Genetic predisposition for increased LDL-c level may decrease efficacy of statin therapy.</p>
DOI10.2217/pgs-2016-0091
Alternate JournalPharmacogenomics
PubMed ID27648687
PubMed Central IDPMC5558541
Grant ListDP1 OD000329 / OD / NIH HHS / United States
MR/K006584/1 / / Medical Research Council / United Kingdom
P30 DK063491 / DK / NIDDK NIH HHS / United States
UL1 TR000124 / TR / NCATS NIH HHS / United States
ePub date: 
16/10