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Catechol-O-Methyltransferase Genotype, Frailty, and Gait Speed in a Biracial Cohort of Older Adults.
Monday,2021-01-25 16:45 America/Los_Angeles — ecterry
| Title | Catechol-O-Methyltransferase Genotype, Frailty, and Gait Speed in a Biracial Cohort of Older Adults. |
| Publication Type | Journal Article |
| Year of Publication | 2020 |
| Authors | Mance, S, Rosso, A, Bis, J, Studenski, S, Bohnen, N, Rosano, C |
| Journal | J Am Geriatr Soc |
| Date Published | 2020 Oct 12 |
| ISSN | 1532-5415 |
| Abstract | <p><b>OBJECTIVE: </b>To examine whether the association between dopamine-related genotype and gait speed differs according to frailty status or race.</p><p><b>DESIGN: </b>Cross-sectional population-based study (Cardiovascular Health Study).</p><p><b>SETTING: </b>Multicenter study, four U.S. sites.</p><p><b>PARTICIPANTS: </b>Volunteer community-dwelling adults aged 65 years and older, without evidence of Parkinson's disease (N = 3,744; 71 years; 82% White; 39% male).</p><p><b>MEASUREMENTS: </b>Gait speed (usual pace; m/s), physical frailty (Fried definition), and genetic polymorphism of catechol-O-methyltransferase (COMT; rs4680), an enzyme regulating tonic brain dopamine levels, were assessed. Interaction of COMT by frailty and by race predicting gait speed were tested, and, if significant, analyses were stratified. Multivariable regression models of COMT predicting gait speed were adjusted for demographics and locomotor risk factors. Sensitivity analyses were repeated, stratified by clinical cutoffs of gait speed (0.6 and 1.0 m/s) instead of frailty status.</p><p><b>RESULTS: </b>The interaction of COMT by frailty and COMT by race were P = .02 and P = .01, respectively. Compared with Met/Met (higher dopaminergic signaling), the Val/Val group (lower dopaminergic signaling) walked marginally more slowly in the full cohort (0.87 vs 0.89 m/s; P = .2). Gait speed differences were significant for frail (n = 220; 0.55 vs 0.63 m/s; P = .03), but not for prefrail (n = 1,691; 0.81 vs 0.81 m/s; P = .9) or nonfrail (n = 1,833; 0.98 vs 0.97 m/s; P = .7); results were similar in fully adjusted models. Among frail, associations were similar for Whites and Blacks, with statistical significance for Whites only. Associations stratified by clinical cutoffs of gait speed were not significant.</p><p><b>CONCLUSION: </b>The association of dopamine-related genotype with gait speed is stronger among adults with frailty compared with those without frailty. The potential effects of dopaminergic signaling on preserving physical function in biracial cohorts of frail adults should be further examined.</p> |
| DOI | 10.1111/jgs.16842 |
| Alternate Journal | J Am Geriatr Soc |
| PubMed ID | 33043988 |
| Grant List | U01HL080295 / HL / NHLBI NIH HHS / United States 1U01AG061393-01 / AG / NIA NIH HHS / United States UL1TR001881 / TR / NCATS NIH HHS / United States DK063491 / DK / NIDDK NIH HHS / United States / NS / NINDS NIH HHS / United States R01AG023629 / AG / NIA NIH HHS / United States / NH / NIH HHS / United States R01HL103612 / HL / NHLBI NIH HHS / United States R01 AG037451 / AG / NIA NIH HHS / United States R01HL105756 / HL / NHLBI NIH HHS / United States U01 AG061393 / AG / NIA NIH HHS / United States R01HL087652 / HL / NHLBI NIH HHS / United States |
ePub date:
20/10