You are here
Metabolites Associated with Walking Ability Among the Oldest Old from the CHS All Stars Study.
Monday,2021-03-01 11:42 America/Los_Angeles — ecterry
| Title | Metabolites Associated with Walking Ability Among the Oldest Old from the CHS All Stars Study. |
| Publication Type | Journal Article |
| Year of Publication | 2020 |
| Authors | Marron, MM, Wendell, SG, Boudreau, RM, Clish, CB, Santanasto, AJ, Tseng, GC, Zmuda, JM, Newman, AB |
| Journal | J Gerontol A Biol Sci Med Sci |
| Volume | 75 |
| Issue | 12 |
| Pagination | 2371-2378 |
| Date Published | 2020 11 13 |
| ISSN | 1758-535X |
| Keywords | Aged, Aged, 80 and over, Case-Control Studies, Female, Geriatric Assessment, Humans, Male, Metabolomics, Risk Factors, Walking, Walking Speed |
| Abstract | <p><b>BACKGROUND: </b>Low walking ability is highly prevalent with advancing age and predicts major health outcomes. Metabolomics may help to better characterize differences in walking ability among older adults, providing insight into potentially altered molecular processes underlying age-related decline in functioning. We sought to identify metabolites and metabolic pathways associated with high versus low walking ability among 120 participants ages 79-95 from the CHS All Stars study.</p><p><b>METHODS: </b>Using a nested case-control design, 60 randomly selected participants with low walking ability were matched one-to-one on age, gender, race, and fasting time with 60 participants with high walking ability. High versus low walking ability was defined as being in the best versus worst tertiles for both gait speed (≥0.9 vs <0.7 m/s) and the Walking Ability Index (7-9 vs 0-1). Using liquid chromatography-mass spectrometry, 569 metabolites were identified in overnight-fasting plasma.</p><p><b>RESULTS: </b>Ninety-six metabolites were associated with walking ability, where 24% were triacylglycerols. Triacylglycerols that were higher among those with high walking ability consisted mostly of polyunsaturated fatty acids, whereas triacylglycerols that were lower among those with high walking ability consisted mostly of saturated or monounsaturated fatty acids. Body composition partly explained associations between some metabolites and walking ability. Proline and arginine metabolism was a top pathway associated with walking ability.</p><p><b>CONCLUSION: </b>These results may partly reflect pathways of modifiable risk factors, including excess dietary lipids and lack of physical activity, contributing to obesity and further alterations in metabolic pathways that lead to age-related decline in walking ability in this older adult cohort.</p> |
| DOI | 10.1093/gerona/glaa030 |
| Alternate Journal | J Gerontol A Biol Sci Med Sci |
| PubMed ID | 31970383 |
| PubMed Central ID | PMC7662173 |
| Grant List | K01 AG057726 / AG / NIA NIH HHS / United States L30 AG064586 / AG / NIA NIH HHS / United States P30 DK040561 / DK / NIDDK NIH HHS / United States T32 HL083825 / HL / NHLBI NIH HHS / United States R01 AG023629 / AG / NIA NIH HHS / United States N01 HC035129 / HC / NHLBI NIH HHS / United States N01 HC045133 / HC / NHLBI NIH HHS / United States N01HC75150 / HL / NHLBI NIH HHS / United States N01HC85079 / HL / NHLBI NIH HHS / United States N01HC85086 / HL / NHLBI NIH HHS / United States N01 HC015103 / HC / NHLBI NIH HHS / United States N01HC55222 / HL / NHLBI NIH HHS / United States U01 HL080295 / HL / NHLBI NIH HHS / United States |
ePub date:
20/11