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Association of Midlife Cardiovascular Risk Factors With the Risk of Heart Failure Subtypes Later in Life.
Wednesday,2021-04-21 15:23 America/Los_Angeles — ecterry
| Title | Association of Midlife Cardiovascular Risk Factors With the Risk of Heart Failure Subtypes Later in Life. |
| Publication Type | Journal Article |
| Year of Publication | 2021 |
| Authors | Cohen, LP, Vittinghoff, E, Pletcher, MJ, Allen, NB, Shah, SJ, Wilkins, JT, Chang, PP, Ndumele, CE, Newman, AB, Ives, D, Maurer, MS, Oelsner, EC, Moran, AE, Zhang, Y |
| Journal | J Card Fail |
| Volume | 27 |
| Issue | 4 |
| Pagination | 435-444 |
| Date Published | 2021 Apr |
| ISSN | 1532-8414 |
| Abstract | <p><b>BACKGROUND: </b>Independent associations between cardiovascular risk factor exposures during midlife and later life development of heart failure (HF) with preserved ejection fraction (HFpEF) versus reduced EF (HFrEF) have not been previously studied.</p><p><b>METHODS: </b>We pooled data from 4 US cohort studies (Atherosclerosis Risk in Communities, Cardiovascular Health, Health , Aging and Body Composition, and Multi-Ethnic Study of Atherosclerosis) and imputed annual risk factor trajectories for body mass index, systolic and diastolic blood pressure, low-density lipoprotein and high-density lipoprotein cholesterol, and glucose starting from age 40 years. Time-weighted average exposures to each risk factor during midlife and later life were calculated and analyzed for associations with the development of HFpEF or HFrEF.</p><p><b>RESULTS: </b>A total of 23,861 participants were included (mean age at first in-person visit, 61.8 ±1 0.2 years; 56.6% female). During a median follow-up of 12 years, there were 3666 incident HF events, of which 51% had EF measured, including 934 with HFpEF and 739 with HFrEF. A high midlife systolic blood pressure and low midlife high-density lipoprotein cholesterol were associated with HFrEF, and a high midlife body mass index, systolic blood pressure, pulse pressure, and glucose were associated with HFpEF. After adjusting for later life exposures, only midlife pulse pressure remained independently associated with HFpEF.</p><p><b>CONCLUSIONS: </b>Midlife exposure to cardiovascular risk factors are differentially associated with HFrEF and HFpEF later in life. Having a higher pulse pressure during midlife is associated with a greater risk for HFpEF but not HFrEF, independent of later life exposures.</p> |
| DOI | 10.1016/j.cardfail.2020.11.008 |
| Alternate Journal | J Card Fail |
| PubMed ID | 33238139 |
| PubMed Central ID | PMC7987686 |
| Grant List | 75N95020D00003 / DA / NIDA NIH HHS / United States HHSN268201500003C / HL / NHLBI NIH HHS / United States 75N90020D00002 / CL / CLC NIH HHS / United States N01HC95160 / HL / NHLBI NIH HHS / United States R01 HL107475 / HL / NHLBI NIH HHS / United States R01 AG028050 / AG / NIA NIH HHS / United States N01HC85080 / HL / NHLBI NIH HHS / United States HHSN268201700003I / HL / NHLBI NIH HHS / United States 75N95020D00004 / DA / NIDA NIH HHS / United States N01HC95163 / HL / NHLBI NIH HHS / United States U01 HL080295 / HL / NHLBI NIH HHS / United States UL1 TR001079 / TR / NCATS NIH HHS / United States 75N96020D00002 / ES / NIEHS NIH HHS / United States 75N93020D00002 / AI / NIAID NIH HHS / United States U01 HL130114 / HL / NHLBI NIH HHS / United States HHSN268200800007C / HL / NHLBI NIH HHS / United States N01HC95169 / HL / NHLBI NIH HHS / United States 75N99020D00003 / OF / ORFDO NIH HHS / United States 75N95020D00002 / DA / NIDA NIH HHS / United States N01HC95164 / HL / NHLBI NIH HHS / United States N01HC55222 / HL / NHLBI NIH HHS / United States N01HC95162 / HL / NHLBI NIH HHS / United States R01 NR012459 / NR / NINR NIH HHS / United States N01HC85086 / HL / NHLBI NIH HHS / United States N01HC95168 / HL / NHLBI NIH HHS / United States 75N90020D00003 / CL / CLC NIH HHS / United States 75N96020D00003 / ES / NIEHS NIH HHS / United States 75N99020D00002 / OF / ORFDO NIH HHS / United States HHSN268201700002C / HL / NHLBI NIH HHS / United States HHSN268201200036C / HL / NHLBI NIH HHS / United States HHSN268201800001C / HL / NHLBI NIH HHS / United States HHSN268201700001I / HL / NHLBI NIH HHS / United States 75N99020D00006 / OF / ORFDO NIH HHS / United States HHSN268201700004I / HL / NHLBI NIH HHS / United States N01HC95165 / HL / NHLBI NIH HHS / United States N01HC95159 / HL / NHLBI NIH HHS / United States 75N95020D00007 / DA / NIDA NIH HHS / United States N01HC95161 / HL / NHLBI NIH HHS / United States UL1 TR001420 / TR / NCATS NIH HHS / United States 75N95020D00005 / DA / NIDA NIH HHS / United States T32 HL007343 / HL / NHLBI NIH HHS / United States HHSN268201500003I / HL / NHLBI NIH HHS / United States 75N92021D00006 / HL / NHLBI NIH HHS / United States HHSN268201700005C / HL / NHLBI NIH HHS / United States HHSN268201700001C / HL / NHLBI NIH HHS / United States N01HC85082 / HL / NHLBI NIH HHS / United States 75N99020D00005 / OF / ORFDO NIH HHS / United States N01HC95167 / HL / NHLBI NIH HHS / United States HHSN268201700003C / HL / NHLBI NIH HHS / United States 75N99020D00007 / OF / ORFDO NIH HHS / United States N01HC85083 / HL / NHLBI NIH HHS / United States K23 HL136853 / HL / NHLBI NIH HHS / United States HHSN268201700004C / HL / NHLBI NIH HHS / United States UL1 TR000040 / TR / NCATS NIH HHS / United States HHSN268201700002I / HL / NHLBI NIH HHS / United States HHSN268201700005I / HL / NHLBI NIH HHS / United States 75N98020D00007 / OD / NIH HHS / United States N01HC85079 / HL / NHLBI NIH HHS / United States N01HC95166 / HL / NHLBI NIH HHS / United States R01 AG023629 / AG / NIA NIH HHS / United States 75N99020D00004 / OF / ORFDO NIH HHS / United States N01HC85081 / HL / NHLBI NIH HHS / United States |
ePub date:
21/04