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Serum Individual Nonesterified Fatty Acids and Risk of Heart Failure in Older Adults.

TitleSerum Individual Nonesterified Fatty Acids and Risk of Heart Failure in Older Adults.
Publication TypeJournal Article
Year of Publication2021
AuthorsDjoussé, L, Biggs, ML, Matthan, NR, Ix, JH, Fitzpatrick, AL, King, I, Lemaitre, RN, McKnight, B, Kizer, JR, Lichtenstein, AH, Mukamal, KJ, Siscovick, DS
JournalCardiology
Pagination1-8
Date Published2021 Feb 25
ISSN1421-9751
Abstract<p><b>BACKGROUND: </b>Heart failure (HF) is highly prevalent among older adults and is associated with high costs. Although serum total nonesterified fatty acids (NEFAs) have been positively associated with HF risk, the contribution of each individual NEFA to HF risk has not been examined.</p><p><b>OBJECTIVE: </b>The aim of this study was to examine the association of individual fasting NEFAs with HF risk in older adults.</p><p><b>METHODS: </b>In this prospective cohort study of older adults, we measured 35 individual NEFAs in 2,140 participants of the Cardiovascular Health Study using gas chromatography. HF was ascertained using review of medical records by an endpoint committee.</p><p><b>RESULTS: </b>The mean age was 77.7 ± 4.4 years, and 38.8% were male. During a median follow-up of 9.7 (maximum 19.0) years, 655 new cases of HF occurred. In a multivariable Cox regression model controlling for demographic and anthropometric variables, field center, education, serum albumin, glomerular filtration rate, physical activity, alcohol consumption, smoking, hormone replacement therapy, unintentional weight loss, and all other measured NEFAs, we observed inverse associations (HR [95% CI] per standard deviation) of nonesterified pentadecanoic (15:0) (0.73 [0.57-0.94]), γ-linolenic acid (GLA) (0.87 [0.75-1.00]), and docosahexaenoic acid (DHA) (0.73 [0.61-0.88]) acids with HF, and positive associations of nonesterified stearic (18:0) (1.30 [1.04-1.63]) and nervonic (24:1n-9) (1.17 [1.06-1.29]) acids with HF.</p><p><b>CONCLUSION: </b>Our data are consistent with a higher risk of HF with nonesterified stearic and nervonic acids and a lower risk with nonesterified 15:0, GLA, and DHA in older adults. If confirmed in other studies, specific NEFAs may provide new targets for HF prevention.</p>
DOI10.1159/000513917
Alternate JournalCardiology
PubMed ID33631767
Grant ListU01 HL080295 / HL / NHLBI NIH HHS / United States
U01 HL130114 / HL / NHLBI NIH HHS / United States
ePub date: 
21/02