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Cardiovascular Risk Factors Across the Life Course and Cognitive Decline: A Pooled Cohort Study.
Tuesday,2021-07-20 19:25 America/Los_Angeles — ecterry
| Title | Cardiovascular Risk Factors Across the Life Course and Cognitive Decline: A Pooled Cohort Study. |
| Publication Type | Journal Article |
| Year of Publication | 2021 |
| Authors | Yaffe, K, Vittinghoff, E, Hoang, T, Matthews, K, Golden, SH, Hazzouri, AZeki Al |
| Journal | Neurology |
| Volume | 96 |
| Issue | 17 |
| Pagination | e2212-e2219 |
| Date Published | 2021 04 27 |
| ISSN | 1526-632X |
| Keywords | Adolescent, Adult, Aged, Aged, 80 and over, Aging, Blood Pressure, Cardiovascular Diseases, Cognition, Cognitive Dysfunction, Cohort Studies, Female, Heart Disease Risk Factors, Humans, Hypertension, Male, Middle Aged, Risk Factors, Young Adult |
| Abstract | <p><b>OBJECTIVE: </b>Cardiovascular risk factors (CVRFs) are associated with increased risk of cognitive decline, but little is known about how early adult CVRFs and those across the life course might influence late-life cognition. To test the hypothesis that CVRFs across the adult life course are associated with late-life cognitive changes, we pooled data from 4 prospective cohorts (n = 15,001, ages 18-95).</p><p><b>METHODS: </b>We imputed trajectories of body mass index (BMI), fasting glucose (FG), systolic blood pressure (SBP), and total cholesterol (TC) for older adults. We used linear mixed models to determine the association of early adult, midlife, and late-life CVRFs with late-life decline on global cognition (Modified Mini-Mental State Examination [3MS]) and processing speed (Digit Symbol Substitution Test [DSST]), adjusting for demographics, education, and cohort.</p><p><b>RESULTS: </b>Elevated BMI, FG, and SBP (but not TC) at each time period were associated with greater late-life decline. Early life CVRFs were associated with the greatest change, an approximate doubling of mean 10-year decline (an additional 3-4 points for 3MS or DSST). Late-life CVRFs were associated with declines in early late life (<80 years) but with gains in very late life (≥80 years). After adjusting for CVRF exposures at all time periods, the associations for early adult and late-life CVRFs persisted.</p><p><b>CONCLUSIONS: </b>We found that imputed CVRFs across the life course, especially in early adulthood, were associated with greater late-life cognitive decline. Our results suggest that CVRF treatment in early adulthood could benefit late-life cognition, but that treatment in very late life may not be as helpful for these outcomes.</p> |
| DOI | 10.1212/WNL.0000000000011747 |
| Alternate Journal | Neurology |
| PubMed ID | 33731482 |
| PubMed Central ID | PMC8166431 |
| Grant List | RF1 AG054443 / AG / NIA NIH HHS / United States K01 AG047273 / AG / NIA NIH HHS / United States HHSN268201800005I / HL / NHLBI NIH HHS / United States HHSN268201800007I / HL / NHLBI NIH HHS / United States HHSN268201800003I / HL / NHLBI NIH HHS / United States HHSN268201800006I / HL / NHLBI NIH HHS / United States HHSN268201800004I / HL / NHLBI NIH HHS / United States HHSN268201500003I / HL / NHLBI NIH HHS / United States N01HC95159 / HL / NHLBI NIH HHS / United States N01HC95160 / HL / NHLBI NIH HHS / United States N01HC95161 / HL / NHLBI NIH HHS / United States N01HC95162 / HL / NHLBI NIH HHS / United States N01HC95163 / HL / NHLBI NIH HHS / United States N01HC95164 / HL / NHLBI NIH HHS / United States N01HC95165 / HL / NHLBI NIH HHS / United States N01HC95166 / HL / NHLBI NIH HHS / United States N01HC95167 / HL / NHLBI NIH HHS / United States N01HC95168 / HL / NHLBI NIH HHS / United States N01HC95169 / HL / NHLBI NIH HHS / United States UL1 TR000040 / TR / NCATS NIH HHS / United States UL1 TR001079 / TR / NCATS NIH HHS / United States UL1 TR001420 / TR / NCATS NIH HHS / United States HHSN268201200036C / HL / NHLBI NIH HHS / United States HHSN268200800007C / HL / NHLBI NIH HHS / United States HHSN268201800001C / HL / NHLBI NIH HHS / United States N01HC55222 / HL / NHLBI NIH HHS / United States N01HC85079 / HL / NHLBI NIH HHS / United States N01HC85080 / HL / NHLBI NIH HHS / United States N01HC85081 / HL / NHLBI NIH HHS / United States N01HC85082 / HL / NHLBI NIH HHS / United States N01HC85083 / HL / NHLBI NIH HHS / United States N01HC85086 / HL / NHLBI NIH HHS / United States U01 HL080295 / HL / NHLBI NIH HHS / United States U01 HL130114 / HL / NHLBI NIH HHS / United States R01 AG023629 / AG / NIA NIH HHS / United States R01 AG028050 / AG / NIA NIH HHS / United States R01 NR012459 / NR / NINR NIH HHS / United States |
ePub date:
21/04