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Sugar-Sweetened Beverage Consumption May Modify Associations Between Genetic Variants in the CHREBP (Carbohydrate Responsive Element Binding Protein) Locus and HDL-C (High-Density Lipoprotein Cholesterol) and Triglyceride Concentrations.
Monday,2021-08-23 17:55 America/Los_Angeles — ecterry
| Title | Sugar-Sweetened Beverage Consumption May Modify Associations Between Genetic Variants in the CHREBP (Carbohydrate Responsive Element Binding Protein) Locus and HDL-C (High-Density Lipoprotein Cholesterol) and Triglyceride Concentrations. |
| Publication Type | Journal Article |
| Year of Publication | 2021 |
| Authors | Haslam, DE, Peloso, GM, Guirette, M, Imamura, F, Bartz, TM, Pitsillides, AN, Wang, CA, Li-Gao, R, Westra, JM, Pitkänen, N, Young, KL, Graff, M, Wood, AC, Braun, KVE, Luan, J'an, Kähönen, M, de Jong, JCKiefte-, Ghanbari, M, Tintle, N, Lemaitre, RN, Mook-Kanamori, DO, North, K, Helminen, M, Mossavar-Rahmani, Y, Snetselaar, L, Martin, LW, Viikari, JS, Oddy, WH, Pennell, CE, Rosendall, FR, Ikram, AM, Uitterlinden, AG, Psaty, BM, Mozaffarian, D, Rotter, JI, Taylor, KD, Lehtimäki, T, Raitakari, OT, Livingston, KA, Voortman, T, Forouhi, NG, Wareham, NJ, de Mutsert, R, Rich, SS, Manson, JAE, Mora, S, Ridker, PM, Merino, J, Meigs, JB, Dashti, HS, Chasman, DI, Lichtenstein, AH, Smith, CE, Dupuis, J, Herman, MA, McKeown, NM |
| Journal | Circ Genom Precis Med |
| Volume | 14 |
| Issue | 4 |
| Pagination | e003288 |
| Date Published | 2021 Aug |
| ISSN | 2574-8300 |
| Abstract | <p><b>BACKGROUND: </b>ChREBP (carbohydrate responsive element binding protein) is a transcription factor that responds to sugar consumption. Sugar-sweetened beverage (SSB) consumption and genetic variants in the locus have separately been linked to HDL-C (high-density lipoprotein cholesterol) and triglyceride concentrations. We hypothesized that SSB consumption would modify the association between genetic variants in the locus and dyslipidemia.</p><p><b>METHODS: </b>Data from 11 cohorts from the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium (N=63 599) and the UK Biobank (N=59 220) were used to quantify associations of SSB consumption, genetic variants, and their interaction on HDL-C and triglyceride concentrations using linear regression models. A total of 1606 single nucleotide polymorphisms within or near were considered. SSB consumption was estimated from validated questionnaires, and participants were grouped by their estimated intake.</p><p><b>RESULTS: </b>In a meta-analysis, rs71556729 was significantly associated with higher HDL-C concentrations only among the highest SSB consumers (β, 2.12 [95% CI, 1.16-3.07] mg/dL per allele; <0.0001), but not significantly among the lowest SSB consumers (=0.81; <0.0001). Similar results were observed for 2 additional variants (rs35709627 and rs71556736). For triglyceride, rs55673514 was positively associated with triglyceride concentrations only among the highest SSB consumers (β, 0.06 [95% CI, 0.02-0.09] ln-mg/dL per allele, =0.001) but not the lowest SSB consumers (=0.84; =0.0005).</p><p><b>CONCLUSIONS: </b>Our results identified genetic variants in the locus that may protect against SSB-associated reductions in HDL-C and other variants that may exacerbate SSB-associated increases in triglyceride concentrations. Registration: URL: https://www.clinicaltrials.gov; Unique identifier: NCT00005133, NCT00005121, NCT00005487, and NCT00000479.</p> |
| DOI | 10.1161/CIRCGEN.120.003288 |
| Alternate Journal | Circ Genom Precis Med |
| PubMed ID | 34270325 |
| Grant List | R01 DK121710 / DK / NIDDK NIH HHS / United States R01 HL105756 / HL / NHLBI NIH HHS / United States T32 CA009001 / CA / NCI NIH HHS / United States |
ePub date:
21/08