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Clonal Hematopoiesis Is Associated With Higher Risk of Stroke.
Friday,2022-03-04 10:35 America/Los_Angeles — ecterry
| Title | Clonal Hematopoiesis Is Associated With Higher Risk of Stroke. |
| Publication Type | Journal Article |
| Year of Publication | 2022 |
| Authors | Bhattacharya, R, Zekavat, SM, Haessler, J, Fornage, M, Raffield, L, Uddin, MMesbah, Bick, AG, Niroula, A, Yu, B, Gibson, C, Griffin, G, Morrison, AC, Psaty, BM, Longstreth, WT, Bis, JC, Rich, SS, Rotter, JI, Tracy, RP, Correa, A, Seshadri, S, Johnson, A, Collins, JM, Hayden, KM, Madsen, TE, Ballantyne, CM, Jaiswal, S, Ebert, BL, Kooperberg, C, Manson, JAE, Whitsel, EA, Natarajan, P, Reiner, AP |
| Corporate/Institutional Authors | NHLBI Trans-Omics for Precision Medicine Program |
| Journal | Stroke |
| Volume | 53 |
| Issue | 3 |
| Pagination | 788-797 |
| Date Published | 2022 Mar |
| ISSN | 1524-4628 |
| Abstract | <p><b>BACKGROUND AND PURPOSE: </b>Clonal hematopoiesis of indeterminate potential (CHIP) is a novel age-related risk factor for cardiovascular disease-related morbidity and mortality. The association of CHIP with risk of incident ischemic stroke was reported previously in an exploratory analysis including a small number of incident stroke cases without replication and lack of stroke subphenotyping. The purpose of this study was to discover whether CHIP is a risk factor for ischemic or hemorrhagic stroke.</p><p><b>METHODS: </b>We utilized plasma genome sequence data of blood DNA to identify CHIP in 78 752 individuals from 8 prospective cohorts and biobanks. We then assessed the association of CHIP and commonly mutated individual CHIP driver genes (, , and ) with any stroke, ischemic stroke, and hemorrhagic stroke.</p><p><b>RESULTS: </b>CHIP was associated with an increased risk of total stroke (hazard ratio, 1.14 [95% CI, 1.03-1.27]; =0.01) after adjustment for age, sex, and race. We observed associations with CHIP with risk of hemorrhagic stroke (hazard ratio, 1.24 [95% CI, 1.01-1.51]; =0.04) and with small vessel ischemic stroke subtypes. In gene-specific association results, showed the strongest association with total stroke and ischemic stroke, whereas and were each associated with increased risk of hemorrhagic stroke.</p><p><b>CONCLUSIONS: </b>CHIP is associated with an increased risk of stroke, particularly with hemorrhagic and small vessel ischemic stroke. Future studies clarifying the relationship between CHIP and subtypes of stroke are needed.</p> |
| DOI | 10.1161/STROKEAHA.121.037388 |
| Alternate Journal | Stroke |
| PubMed ID | 34743536 |
| PubMed Central ID | PMC8885769 |
| Grant List | R01 HL151283 / HL / NHLBI NIH HHS / United States R01 HL148565 / HL / NHLBI NIH HHS / United States R01 HL105756 / HL / NHLBI NIH HHS / United States T32 HL129982 / HL / NHLBI NIH HHS / United States R01 HL136574 / HL / NHLBI NIH HHS / United States R01 HL148050 / HL / NHLBI NIH HHS / United States |
ePub date:
21/11