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What Cut-Point in Gait Speed Best Discriminates Community-Dwelling Older Adults With Mobility Complaints From Those Without? A Pooled Analysis From the Sarcopenia Definitions and Outcomes Consortium.
Friday,2022-03-04 10:48 America/Los_Angeles — ecterry
| Title | What Cut-Point in Gait Speed Best Discriminates Community-Dwelling Older Adults With Mobility Complaints From Those Without? A Pooled Analysis From the Sarcopenia Definitions and Outcomes Consortium. |
| Publication Type | Journal Article |
| Year of Publication | 2021 |
| Authors | Cawthon, PM, Patel, SM, Kritchevsky, SB, Newman, AB, Santanasto, A, Kiel, DP, Travison, TG, Lane, N, Cummings, SR, Orwoll, ES, Duchowny, KA, Kwok, T, Hirani, V, Schousboe, J, Karlsson, MK, Mellström, D, Ohlsson, C, Ljunggren, O, Xue, Q-L, Shardell, M, Jordan, JM, Pencina, KM, Fielding, RA, Magaziner, J, Correa-de-Araujo, R, Bhasin, S, Manini, TM |
| Journal | J Gerontol A Biol Sci Med Sci |
| Volume | 76 |
| Issue | 10 |
| Pagination | e321-e327 |
| Date Published | 2021 09 13 |
| ISSN | 1758-535X |
| Keywords | Aged, Female, Gait, Humans, Independent Living, Male, Mobility Limitation, Sarcopenia, Walking, Walking Speed |
| Abstract | <p><b>BACKGROUND: </b>Cut-points to define slow walking speed have largely been derived from expert opinion.</p><p><b>METHODS: </b>Study participants (13 589 men and 5043 women aged ≥65years) had walking speed (m/s) measured over 4-6 m (mean ± SD: 1.20 ± 0.27 m/s in men and 0.94 ± 0.24 m/s in women.) Mobility limitation was defined as any self-reported difficulty with walking approximately 1/4 mile (prevalence: 12.6% men, 26.4% women). Sex-stratified classification and regression tree (CART) models with 10-fold cross-validation identified walking speed cut-points that optimally discriminated those who reported mobility limitation from those who did not.</p><p><b>RESULTS: </b>Among 5043 women, CART analysis identified 2 cut-points, classifying 4144 (82.2%) with walking speed ≥0.75 m/s, which we labeled as "fast"; 478 (9.5%) as "intermediate" (walking speed ≥0.62 m/s but <0.75 m/s); and 421 (8.3%) as "slow" (walking speed <0.62 m/s). Among 13 589 men, CART analysis identified 3 cut-points, classifying 10 001 (73.6%) with walking speed ≥1.00 m/s ("very fast"); 2901 (21.3%) as "fast" (walking speed ≥0.74 m/s but <1.00 m/s); 497 (3.7%) as "intermediate" (walking speed ≥0.57 m/s but <0.74 m/s); and 190 (1.4%) as "slow" (walking speed <0.57 m/s). Prevalence of self-reported mobility limitation was lowest in the "fast" or "very fast" (11% for men and 19% for women) and highest in the "slow" (60.5% in men and 71.0% in women). Rounding the 2 slower cut-points to 0.60 m/s and 0.75 m/s reclassified very few participants.</p><p><b>CONCLUSIONS: </b>Cut-points in walking speed of approximately 0.60 m/s and 0.75 m/s discriminate those with self-reported mobility limitation from those without.</p> |
| DOI | 10.1093/gerona/glab183 |
| Alternate Journal | J Gerontol A Biol Sci Med Sci |
| PubMed ID | 34166490 |
| PubMed Central ID | PMC8436986 |
| Grant List | U01 AG051421 / AG / NIA NIH HHS / United States AG51421 / AG / NIA NIH HHS / United States K01 AG057726 / AG / NIA NIH HHS / United States U01 AG027810 / AG / NIA NIH HHS / United States U01 AG042124 / AG / NIA NIH HHS / United States U01 AG042139 / AG / NIA NIH HHS / United States U01 AG042140 / AG / NIA NIH HHS / United States U01 AG042143 / AG / NIA NIH HHS / United States U01 AG042145 / AG / NIA NIH HHS / United States U01 AG042168 / AG / NIA NIH HHS / United States U01 AR066160 / AR / NIAMS NIH HHS / United States UL1 TR000128 / TR / NCATS NIH HHS / United States R01 AG005407 / AG / NIA NIH HHS / United States R01 AR035582 / AR / NIAMS NIH HHS / United States R01 AR035583 / AR / NIAMS NIH HHS / United States R01 AR035584 / AR / NIAMS NIH HHS / United States R01 AG005394 / AG / NIA NIH HHS / United States R01 AG027574 / AG / NIA NIH HHS / United States R01 AG027576 / AG / NIA NIH HHS / United States N01 AG062101 / AG / NIA NIH HHS / United States N01 AG062103 / AG / NIA NIH HHS / United States N01 AG062106 / AG / NIA NIH HHS / United States HHSN268201200036C / HL / NHLBI NIH HHS / United States HHSN268200800007C / HL / NHLBI NIH HHS / United States HHSN268201800001C / HL / NHLBI NIH HHS / United States N01HC55222 / HL / NHLBI NIH HHS / United States N01HC85079 / HL / NHLBI NIH HHS / United States N01HC85080 / HL / NHLBI NIH HHS / United States N01HC85081 / HL / NHLBI NIH HHS / United States N01HC85082 / HL / NHLBI NIH HHS / United States N01HC85083 / HL / NHLBI NIH HHS / United States N01HC85086 / HL / NHLBI NIH HHS / United States U01 HL080295 / HL / NHLBI NIH HHS / United States U01 HL130114 / HL / NHLBI NIH HHS / United States R01 AG023629 / AG / NIA NIH HHS / United States P60 AR030701 / AR / NIAMS NIH HHS / United States P60 AR049465 / AR / NIAMS NIH HHS / United States |
ePub date:
21/09