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Associations of Body Mass Index and Waist Circumference in Young Adulthood with Later Life Incident Diabetes.
Friday,2022-03-04 15:03 America/Los_Angeles — ecterry
| Title | Associations of Body Mass Index and Waist Circumference in Young Adulthood with Later Life Incident Diabetes. |
| Publication Type | Journal Article |
| Year of Publication | 2021 |
| Authors | Nair, N, Vittinghoff, E, Pletcher, MJ, Oelsner, EC, Allen, NB, Ndumele, CE, West, NA, Strotmeyer, ES, Mukamal, KJ, Siscovick, DS, Biggs, ML, Laferrère, B, Moran, AE, Zhang, Y |
| Journal | J Clin Endocrinol Metab |
| Volume | 106 |
| Issue | 12 |
| Pagination | e5011-e5020 |
| Date Published | 2021 11 19 |
| ISSN | 1945-7197 |
| Keywords | Adolescent, Adult, Biomarkers, Body Mass Index, Diabetes Mellitus, Female, Follow-Up Studies, Humans, Male, Obesity, Overweight, Prognosis, Prospective Studies, Risk Factors, United States, Waist Circumference, Young Adult |
| Abstract | <p><b>CONTEXT: </b>The independent contribution of young adult exposure to overweight and obesity to later-life incident diabetes is not well studied.</p><p><b>OBJECTIVE: </b>To assess the associations of exposures to elevated body mass index (BMI) and waist circumference (WC) in young adulthood (ages 18-39 years) with incident diabetes later in life (≥40 years).</p><p><b>DESIGN: </b>Pooled data from 6 US prospective cohorts (Atherosclerosis Risk in Communities Study, Cardiovascular Risk Development in Young Adults Study, Cardiovascular Health Study, (4) Framingham Heart Study Offspring Cohort, (5) Health, Aging and Body Composition Study, and (6) Multi-Ethnic Study of Atherosclerosis.</p><p><b>SETTING: </b>Population-based cohort studies.</p><p><b>PARTICIPANTS: </b>30 780 participants (56.1% female, 69.8% non-Hispanic white) without a diagnosis of diabetes by age 40.</p><p><b>INTERVENTIONS: </b>We imputed BMI and WC trajectories from age 18 for every participant and estimated time-weighted average exposures to BMI or WC during young adulthood and later life.</p><p><b>MAIN OUTCOME MEASURE(S): </b>Incident diabetes defined as fasting glucose ≥126 mg/dL, nonfasting glucose ≥200 mg/dL, or use of diabetes medications.</p><p><b>RESULTS: </b>During a 9-year median follow-up, 4323 participants developed incident diabetes. Young adult BMI and WC were associated with later-life incident diabetes after controlling for later-life exposures [hazard ratios (HR) 1.99 for BMI ≥ 30 kg/m2 and 2.13 for WC > 88cm (women)/>102cm (men) compared to normal ranges]. Young adult homeostatic model of insulin resistance mediated 49% and 44% of the association between BMI and WC with later-life incident diabetes. High-density lipoproteins and triglycerides mediated a smaller proportion of these associations.</p><p><b>CONCLUSIONS: </b>Elevated BMI and WC during young adulthood were independently associated with later-life incident diabetes. Insulin resistance may be a key mediator.</p> |
| DOI | 10.1210/clinem/dgab551 |
| Alternate Journal | J Clin Endocrinol Metab |
| PubMed ID | 34302728 |
| PubMed Central ID | PMC8864746 |
| Grant List | N01 HC095163 / HC / NHLBI NIH HHS / United States N01 HC095168 / HC / NHLBI NIH HHS / United States N01HC95169 / HL / NHLBI NIH HHS / United States N01 HC095169 / HC / NHLBI NIH HHS / United States HHSN268201700002I / HL / NHLBI NIH HHS / United States HHSN268201500003I / HL / NHLBI NIH HHS / United States N01HC85083 / HL / NHLBI NIH HHS / United States HHSN268200800007C / HL / NHLBI NIH HHS / United States N01 HC095164 / HC / NHLBI NIH HHS / United States HHSN268201800004I / HL / NHLBI NIH HHS / United States T32 DK007271 / DK / NIDDK NIH HHS / United States HHSN268201800003I / HL / NHLBI NIH HHS / United States N01HC95160 / HL / NHLBI NIH HHS / United States N01 AG062103 / AG / NIA NIH HHS / United States HHSN268201800001C / HL / NHLBI NIH HHS / United States HHSN268201800005I / HL / NHLBI NIH HHS / United States N01HC95163 / HL / NHLBI NIH HHS / United States U01 HL080295 / HL / NHLBI NIH HHS / United States UL1 TR001079 / TR / NCATS NIH HHS / United States N01 HC085082 / HC / NHLBI NIH HHS / United States HHSN268201200036C / HL / NHLBI NIH HHS / United States N01 AG062106 / AG / NIA NIH HHS / United States U01 HL130114 / HL / NHLBI NIH HHS / United States R01-NR012459 / NR / NINR NIH HHS / United States R01 HL107475 / HL / NHLBI NIH HHS / United States HHSN268201700004I / HL / NHLBI NIH HHS / United States N01 HC095162 / HC / NHLBI NIH HHS / United States N01HC95164 / HL / NHLBI NIH HHS / United States N01 HC085086 / HC / NHLBI NIH HHS / United States N01HC55222 / HL / NHLBI NIH HHS / United States N01 HC095165 / HC / NHLBI NIH HHS / United States N01HC95162 / HL / NHLBI NIH HHS / United States R01 NR012459 / NR / NINR NIH HHS / United States N01HC85086 / HL / NHLBI NIH HHS / United States N01HC95168 / HL / NHLBI NIH HHS / United States HHSN268201500001I / HL / NHLBI NIH HHS / United States HHSN268201800007I / HL / NHLBI NIH HHS / United States N01 HC095159 / HC / NHLBI NIH HHS / United States N01HC95165 / HL / NHLBI NIH HHS / United States N01HC95159 / HL / NHLBI NIH HHS / United States N01 HC095161 / HC / NHLBI NIH HHS / United States R21 HL129924 / HL / NHLBI NIH HHS / United States HHSN268201700005I / HL / NHLBI NIH HHS / United States N01HC95161 / HL / NHLBI NIH HHS / United States UL1 TR001420 / TR / NCATS NIH HHS / United States HHSN268201700003I / HL / NHLBI NIH HHS / United States R01 AG028050 / AG / NIA NIH HHS / United States HHSN268201700001I / HL / NHLBI NIH HHS / United States R01 HL130500 / HL / NHLBI NIH HHS / United States N01HC85082 / HL / NHLBI NIH HHS / United States N01 HC095166 / HC / NHLBI NIH HHS / United States N01HC95167 / HL / NHLBI NIH HHS / United States #N01-AG-6-2101 / AG / NIA NIH HHS / United States N01HC95166 / HL / NHLBI NIH HHS / United States UL1 TR000040 / TR / NCATS NIH HHS / United States HHSN268201800006I / HL / NHLBI NIH HHS / United States K23 HL130627 / HL / NHLBI NIH HHS / United States R01 AG023629 / AG / NIA NIH HHS / United States N01HC85079 / HL / NHLBI NIH HHS / United States N01 HC085080 / HC / NHLBI NIH HHS / United States N01 HC095167 / HC / NHLBI NIH HHS / United States N01HC85080 / HL / NHLBI NIH HHS / United States N01HC85081 / HL / NHLBI NIH HHS / United States N01 HC095160 / HC / NHLBI NIH HHS / United States |
ePub date:
21/11