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White matter grade and ventricular volume on brain MRI as markers of longevity in the cardiovascular health study.
Tuesday,2012-11-06 12:07 America/Los_Angeles — eenright
| Title | White matter grade and ventricular volume on brain MRI as markers of longevity in the cardiovascular health study. |
| Publication Type | Journal Article |
| Year of Publication | 2007 |
| Authors | Kuller, LH, Arnold, AM, Longstreth, WT, Manolio, TA, O'Leary, DH, Burke, GL, Fried, LP, Newman, AB |
| Journal | Neurobiol Aging |
| Volume | 28 |
| Issue | 9 |
| Pagination | 1307-15 |
| Date Published | 2007 Sep |
| ISSN | 1558-1497 |
| Keywords | African Continental Ancestry Group, Aged, Aged, 80 and over, Biomarkers, Brain, Cardiovascular Diseases, Cerebral Ventricles, European Continental Ancestry Group, Female, Geriatric Assessment, Health Status, Humans, Longitudinal Studies, Magnetic Resonance Imaging, Male, Retrospective Studies, Risk Factors, Sex Factors |
| Abstract | <p>High white matter grade (WMG) on magnetic resonance imaging (MRI) is a risk factor for dementia, stroke and disability. Higher ventricular size is a marker of brain "atrophy." In the Cardiovascular Health Study (CHS) (n=3245) mean age 75 years, 50% black and 40% men, we evaluated WM and ventricular grade (VG), total, cardiovascular and noncardiovascular mortality and longevity before and after adjusting for numerous determinants of longevity over an approximate 10-12 years of follow-up. A low WMG and VG was a marker for low total, cardiovascular and noncardiovascular mortality and for increased longevity over 10+ years of follow-up. We estimated that a 75-year-old with WMG below median would have about a 5-6 years greater longevity and for VG about 3 years, than above the median even after adjustment for numerous risk factors. Low WMG and VG on MRI is a powerful determinant of long-term survival among older individuals.</p> |
| DOI | 10.1016/j.neurobiolaging.2006.06.010 |
| Alternate Journal | Neurobiol Aging |
| PubMed ID | 16857296 |
| Grant List | N01-85079 / / PHS HHS / United States N01-HC-15103 / HC / NHLBI NIH HHS / United States N01-HC-15129 / HC / NHLBI NIH HHS / United States N01-HC-85086 / HC / NHLBI NIH HHS / United States |