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{An association test of the spatial distribution of rare missense variants within protein structures identifies Alzheimer's disease-related patterns
Wednesday,2022-07-20 21:20 America/Los_Angeles — ecterry
| Title | {An association test of the spatial distribution of rare missense variants within protein structures identifies Alzheimer's disease-related patterns |
| Publication Type | Journal Article |
| Year of Publication | 2022 |
| Authors | Jin, B, Capra, JA, Benchek, P, Wheeler, N, Naj, AC, Hamilton-Nelson, KL, Farrell, JJ, Leung, YY, Kunkle, B, Vadarajan, B, Schellenberg, GD, Mayeux, R, Wang, LS, Farrer, LA, Pericak-Vance, MA, Martin, ER, Haines, JL, Crawford, DC, Bush, WS |
| Journal | Genome Res |
| Volume | 32 |
| Pagination | 778–790 |
| Date Published | 04 |
| Abstract | is a novel AD risk gene that has a cluster of variants primarily shared by case subjects around the Sec6 domain. This cluster is also validated in an independent replication data set and a validation data set with a larger sample size. |
ePub date:
22/04