You are here
A multi-ethnic polygenic risk score is associated with hypertension prevalence and progression throughout adulthood.
Thursday,2022-07-21 19:06 America/Los_Angeles — ecterry
| Title | A multi-ethnic polygenic risk score is associated with hypertension prevalence and progression throughout adulthood. |
| Publication Type | Journal Article |
| Year of Publication | 2022 |
| Authors | Kurniansyah, N, Goodman, MO, Kelly, TN, Elfassy, T, Wiggins, KL, Bis, JC, Guo, X, Palmas, W, Taylor, KD, Lin, HJ, Haessler, J, Gao, Y, Shimbo, D, Smith, JA, Yu, B, Feofanova, EV, Smit, RAJ, Wang, Z, Hwang, S-J, Liu, S, Wassertheil-Smoller, S, Manson, JAE, Lloyd-Jones, DM, Rich, SS, Loos, RJF, Redline, S, Correa, A, Kooperberg, C, Fornage, M, Kaplan, RC, Psaty, BM, Rotter, JI, Arnett, DK, Morrison, AC, Franceschini, N, Levy, D, Sofer, T |
| Corporate/Institutional Authors | NHLBI Trans-Omics in Precision Medicine (TOPMed) Consortium |
| Journal | Nat Commun |
| Volume | 13 |
| Issue | 1 |
| Pagination | 3549 |
| Date Published | 2022 Jun 21 |
| ISSN | 2041-1723 |
| Keywords | Adult, Diabetes Mellitus, Type 2, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Hypertension, Multifactorial Inheritance, Prevalence, Risk Factors |
| Abstract | <p>In a multi-stage analysis of 52,436 individuals aged 17-90 across diverse cohorts and biobanks, we train, test, and evaluate a polygenic risk score (PRS) for hypertension risk and progression. The PRS is trained using genome-wide association studies (GWAS) for systolic, diastolic blood pressure, and hypertension, respectively. For each trait, PRS is selected by optimizing the coefficient of variation (CV) across estimated effect sizes from multiple potential PRS using the same GWAS, after which the 3 trait-specific PRSs are combined via an unweighted sum called "PRSsum", forming the HTN-PRS. The HTN-PRS is associated with both prevalent and incident hypertension at 4-6 years of follow up. This association is further confirmed in age-stratified analysis. In an independent biobank of 40,201 individuals, the HTN-PRS is confirmed to be predictive of increased risk for coronary artery disease, ischemic stroke, type 2 diabetes, and chronic kidney disease.</p> |
| DOI | 10.1038/s41467-022-31080-2 |
| Alternate Journal | Nat Commun |
| PubMed ID | 35729114 |
| PubMed Central ID | PMC9213527 |
ePub date:
22/06