You are here
Associations of modifiable behavioral risk factor combinations at 65-74 years old with cognitive healthspan over 20 years.
Thursday,2022-07-21 21:16 America/Los_Angeles — ecterry
| Title | Associations of modifiable behavioral risk factor combinations at 65-74 years old with cognitive healthspan over 20 years. |
| Publication Type | Journal Article |
| Year of Publication | 2022 |
| Authors | Smagula, SF, Biggs, ML, Jacob, ME, Rawlings, AM, Odden, MC, Arnold, A, Newman, AB, Buysse, DJ |
| Journal | Psychosom Med |
| Date Published | 2022 Jun 28 |
| ISSN | 1534-7796 |
| Abstract | <p><b>OBJECTIVE: </b>Behavioral risk factors for dementia tend to co-occur and inter-relate, especially poor diet, physical inactivity, sleep disturbances, and depression. Having multiple of these modifiable behavioral risk factors (MBRFs) may predict a particularly shortened cognitive healthspan, and therefore, may signal high-risk status/high intervention need.</p><p><b>METHODS: </b>This secondary analyses of data from the Cardiovascular Health Study included 3149 participants aged 65-74 years (mean age = 69.5, standard deviation (SD) = 2.5; 59.6% female). MBRF exposures were self-reports regarding: (1) diet, (2) activity, (3) sleep, and (4) depression symptoms. We primarily analyzed MBRF counts. Over up to 26 years of follow-up, we assessed the: (1) number of remaining cognitively healthy life years (CHLYs); and (2) percentage of remaining life years (LYs) that were CHLYs (%CHLY). We estimated CHLYs as time before a dementia diagnosis, cognitive screener scores indicating impairment, proxy port indicating significant cognitive decline, or dementia medication use.</p><p><b>RESULTS: </b>Participants averaged a remaining 16 LYs (SD = 7), 12.2 CHLYs (SD = 6.6), and 78.1% of LYs being CHLYs (SD = 25.6). Compared with having no MBRFs, having one was associated with ~1 less LY and CHLY, but not a relatively lower %CHLY. In contrast, having 3+ MBRFs was associated with about 2-3 fewer LYs and CHLYs as well as about 6% lower %CHLY (95% confidence interval: -9.0, -2.5 %CHLYs), p = 0.001).</p><p><b>CONCLUSIONS: </b>MBRF-related reductions in the cognitive healthspan are most apparent when people have multiple MBRFs. Future research is needed to determine if/how behavioral risks converge mechanistically, and if dementia prevention efficacy improves when targeting MBRF combinations.</p> |
| DOI | 10.1097/PSY.0000000000001100 |
| Alternate Journal | Psychosom Med |
| PubMed ID | 35796682 |
ePub date:
22/06