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The Associations of Individual and Subclasses of Non-Esterified Fatty Acids with Disability, and Mobility Limitation in Older Adults: the Cardiovascular Health Study.
Monday,2022-10-10 12:59 America/Los_Angeles — ecterry
| Title | The Associations of Individual and Subclasses of Non-Esterified Fatty Acids with Disability, and Mobility Limitation in Older Adults: the Cardiovascular Health Study. |
| Publication Type | Journal Article |
| Year of Publication | 2022 |
| Authors | Ahiawodzi, P, Bůzková, P, Lichtenstein, AH, Matthan, NR, Ix, JH, Kizer, JR, Tracy, RP, Arnold, A, Newman, AB, Siscovick, D, Djoussé, L, Mukamal, KJ |
| Journal | J Gerontol A Biol Sci Med Sci |
| Date Published | 2022 Sep 26 |
| ISSN | 1758-535X |
| Abstract | <p><b>BACKGROUND: </b>We sought to determine the associations between individual non-esterified fatty acids (NEFAs) and disability and mobility limitation.</p><p><b>METHODS: </b>We studied 1734 participants in the Cardiovascular Health Study (CHS), an ongoing population-based cohort study of community-living older American adults. We measured 35 individual NEFA species in fasting serum samples obtained at the 1996-1997 clinic visit. Using yearly assessments of activities of daily living and self-reported mobility, we identified participants with incident disability or mobility limitation during 15 years of follow-up. Cox proportional hazards regression models were used to determine the associations between per-SD increment in the individual NEFAs and incident disability and mobility limitations with adjustment for potential confounding factors.</p><p><b>RESULTS: </b>Higher concentrations of total and a broad range of individual NEFA species were associated with risk of disability and mobility limitation [disability: HR per SD of total NEFA (SD=174.70) =1.11, 95%CI=1.04-1.18, p=0.001; mobility limitation: HR per SD of total NEFA=1.09, 95%CI=1.02-1.16, p=0.01). Among individual saturated NEFAs (SFAs), myristic (14:0) and palmitic (16:0) acids were significantly associated with higher risk of both disability and mobility limitations, but longer-chain FAs were not. Most individual monounsaturated (MUFA), n-6 polyunsaturated fatty acids (PUFAs), and trans FAs were positively significantly associated with higher risks of both disability and mobility limitation. In contrast, most n-3 PUFA species were not associated with disability or mobility limitation.</p><p><b>CONCLUSIONS: </b>Higher risks of disability and mobility limitation were observed for pro-inflammatory intermediate-chain SFAs, MUFAs, n-6 PUFAs, and trans FAs. Our findings indicated no significant association for anti-inflammatory n-3 PUFAs.</p> |
| DOI | 10.1093/gerona/glac206 |
| Alternate Journal | J Gerontol A Biol Sci Med Sci |
| PubMed ID | 36156076 |
ePub date:
22/09