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Association of immune cell subsets with incident heart failure in two population-based cohorts.
Wednesday,2022-10-12 15:21 America/Los_Angeles — ecterry
| Title | Association of immune cell subsets with incident heart failure in two population-based cohorts. |
| Publication Type | Journal Article |
| Year of Publication | 2022 |
| Authors | Sinha, A, Sitlani, CM, Doyle, MF, Fohner, AE, Bůzková, P, Floyd, JS, Huber, SA, Olson, NC, Njoroge, JN, Kizer, JR, Delaney, JA, Shah, SS, Tracy, RP, Psaty, B, Feinstein, M |
| Journal | ESC Heart Fail |
| Date Published | 2022 Sep 12 |
| ISSN | 2055-5822 |
| Abstract | <p><b>AIMS: </b>Circulating inflammatory markers are associated with incident heart failure (HF), but prospective data on associations of immune cell subsets with incident HF are lacking. We determined the associations of immune cell subsets with incident HF as well as HF subtypes [with reduced ejection fraction (HFrEF) and preserved ejection fraction (HFpEF)].</p><p><b>METHODS AND RESULTS: </b>Peripheral blood immune cell subsets were measured in adults from the Multi-Ethnic Study of Atherosclerosis (MESA) and Cardiovascular Health Study (CHS). Cox proportional hazard models adjusted for demographics, HF risk factors, and cytomegalovirus serostatus were used to evaluate the association of the immune cell subsets with incident HF. The average age of the MESA cohort at the time of immune cell measurements was 63.0 ± 10.4 years with 51% women, and in the CHS cohort, it was 79.6 ± 4.4 years with 62% women. In the meta-analysis of CHS and MESA, a higher proportion of CD4+ T helper (Th) 1 cells (per one standard deviation) was associated with a lower risk of incident HF [hazard ratio (HR) 0.91, (95% CI 0.83-0.99), P = 0.03]. Specifically, higher proportion of CD4+ Th1 cells was significantly associated with a lower risk of HFrEF [HR 0.73, (95% CI 0.62-0.85), <0.001] after correction for multiple testing. No association was observed with HFpEF. No other cell subsets were associated with incident HF.</p><p><b>CONCLUSIONS: </b>We observed that higher proportions of CD4+ Th1 cells were associated with a lower risk of incident HFrEF in two distinct population-based cohorts, with similar effect sizes in both cohorts demonstrating replicability. Although unexpected, the consistency of this finding across cohorts merits further investigation.</p> |
| DOI | 10.1002/ehf2.14140 |
| Alternate Journal | ESC Heart Fail |
| PubMed ID | 36097332 |
| Grant List | UL1-TR-000040 / TR / NCATS NIH HHS / United States UL1-TR-001079 / TR / NCATS NIH HHS / United States UL1-TR-001420 / TR / NCATS NIH HHS / United States KL2TR001424 / TR / NCATS NIH HHS / United States HHSN268201500003I / HL / NHLBI NIH HHS / United States N01-HC-95159 / HL / NHLBI NIH HHS / United States N01-HC-95160 / HL / NHLBI NIH HHS / United States N01-HC-95161 / HL / NHLBI NIH HHS / United States N01-HC-95162 / HL / NHLBI NIH HHS / United States N01-HC-95163 / HL / NHLBI NIH HHS / United States N01-HC-95164 / HL / NHLBI NIH HHS / United States N01-HC-95165 / HL / NHLBI NIH HHS / United States N01-HC-95166 / HL / NHLBI NIH HHS / United States N01-HC-95167 / HL / NHLBI NIH HHS / United States N01-HC-95168 / HL / NHLBI NIH HHS / United States N01-HC-95169 / HL / NHLBI NIH HHS / United States HHSN268201200036C / HL / NHLBI NIH HHS / United States HHSN268200800007C / HL / NHLBI NIH HHS / United States HHSN268201800001C / HL / NHLBI NIH HHS / United States N01HC55222 / HL / NHLBI NIH HHS / United States N01HC85079 / HL / NHLBI NIH HHS / United States N01HC85080 / HL / NHLBI NIH HHS / United States N01HC85081 / HL / NHLBI NIH HHS / United States N01HC85082 / HL / NHLBI NIH HHS / United States N01HC85083 / HL / NHLBI NIH HHS / United States N01HC85086 / HL / NHLBI NIH HHS / United States 75N92021D00006 / HL / NHLBI NIH HHS / United States U01HL080295 / HL / NHLBI NIH HHS / United States R01HL087652 / HL / NHLBI NIH HHS / United States R01HL103612 / HL / NHLBI NIH HHS / United States R01HL120393 / HL / NHLBI NIH HHS / United States R01HL144483 / HL / NHLBI NIH HHS / United States R01HL120854 / HL / NHLBI NIH HHS / United States U01HL130114 / HL / NHLBI NIH HHS / United States R01144483 / HL / NHLBI NIH HHS / United States R01 HL156792 / HL / NHLBI NIH HHS / United States R01 HL98077 / HL / NHLBI NIH HHS / United States 75N92020D00007 / HL / NHLBI NIH HHS / United States 75N92020D00004 / HL / NHLBI NIH HHS / United States 75N92020D00006 / HL / NHLBI NIH HHS / United States 75N92020D00003 / HL / NHLBI NIH HHS / United States 75N92020D00002 / HL / NHLBI NIH HHS / United States 75N92020D00005 / HL / NHLBI NIH HHS / United States 75N92020D00001 / HL / NHLBI NIH HHS / United States R01AG023629 / AG / NIA NIH HHS / United States / NS / NINDS NIH HHS / United States |
ePub date:
22/09