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Sex- and race-specific associations of bone mineral density with incident heart failure and its subtypes in older adults.
Tuesday,2023-01-31 12:53 America/Los_Angeles — ecterry
| Title | Sex- and race-specific associations of bone mineral density with incident heart failure and its subtypes in older adults. |
| Publication Type | Journal Article |
| Year of Publication | 2022 |
| Authors | Gao, H, Patel, S, Fohtung, RB, Cawthon, PM, Newman, AB, Cauley, JA, Carbone, L, Chaves, PHM, Stein, PK, Civitelli, R, Kizer, JR |
| Journal | J Am Geriatr Soc |
| Date Published | 2022 Nov 05 |
| ISSN | 1532-5415 |
| Abstract | <p><b>BACKGROUND: </b>Previous studies have suggested an association between bone mineral density (BMD) and heart failure (HF) risk that may be race-dependent.</p><p><b>METHODS: </b>We evaluated the relationship between BMD and incident HF in a cohort of older adults, the Health, Aging, and Body Composition (Health ABC) study (n = 2835), and next performed a pooled analysis involving a second older cohort, the Cardiovascular Health Study (n = 1268). Hip BMD was measured by dual-energy X-ray absorptiometry in both cohorts and spine BMD by computed tomography in a subset from Health ABC.</p><p><b>RESULTS: </b>In Health ABC, lower BMD at the total hip was associated with higher incident HF in Black women after multivariable adjustment. Similar associations were found for BMD at the femoral neck and spine. In both cohorts, pooled analysis again revealed an association between lower total hip BMD and increased risk of HF in Black women (HR = 1.41 per 0.1-g/cm decrement [95% CI = 1.23-1.62]), and showed the same to be true for White men (HR = 1.12 [1.03-1.21]). There was a decreased risk of HF in Black men (HR 0.80 [0.70-0.91]), but no relationship in White women. The associations were numerically stronger with HFpEF for Black women and White men, and with HFrEF for Black men. Findings were similar for femoral neck BMD. Sensitivity analyses delaying HF follow-up by 2 years eliminated the association in Black men.</p><p><b>CONCLUSIONS: </b>Lower BMD was associated with higher risk of HF and especially HFpEF in older Black women and White men, highlighting the need for additional investigation into underlying mechanisms.</p> |
| DOI | 10.1111/jgs.18121 |
| Alternate Journal | J Am Geriatr Soc |
| PubMed ID | 36334030 |
| Grant List | U01HL080295 / HL / NHLBI NIH HHS / United States / NS / NINDS NIH HHS / United States R01AG023629 / AG / NIA NIH HHS / United States U01HL130114 / HL / NHLBI NIH HHS / United States K24 HL135413 / HL / NHLBI NIH HHS / United States R01 AG053325 / AG / NIA NIH HHS / United States U01 HL130114 / HL / NHLBI NIH HHS / United States R01-AG028050 / AG / NIA NIH HHS / United States R01-NR012459 / NR / NINR NIH HHS / United States |
ePub date:
22/11