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Association of Obesity With Cognitive Decline in Black and White Americans.
Tuesday,2023-02-28 15:35 America/Los_Angeles — ecterry
| Title | Association of Obesity With Cognitive Decline in Black and White Americans. |
| Publication Type | Journal Article |
| Year of Publication | 2023 |
| Authors | Quaye, E, Galecki, AT, Tilton, N, Whitney, R, Briceño, EM, Elkind, MSV, Fitzpatrick, AL, Gottesman, RF, Griswold, M, Gross, AL, Heckbert, SR, Hughes, TM, Longstreth, WT, Sacco, RL, Sidney, S, B Windham, G, Yaffe, K, Levine, DA |
| Journal | Neurology |
| Volume | 100 |
| Issue | 2 |
| Pagination | e220-e231 |
| Date Published | 2023 Jan 10 |
| ISSN | 1526-632X |
| Keywords | Aged, Black or African American, Cognition, Cognitive Dysfunction, Female, Humans, Male, Middle Aged, Obesity, Risk Factors, United States, White |
| Abstract | <p><b>BACKGROUND AND OBJECTIVES: </b>There are disparities in the prevalence of obesity by race, and the relationship between obesity and cognitive decline is unclear. The objective of this study was to determine whether obesity is independently associated with cognitive decline and whether the association between obesity and cognitive decline differs in Black and White adults. We hypothesized that obesity is associated with greater cognitive decline compared with normal weight and that the effect of obesity on cognitive decline is more pronounced in Black adults compared with their White counterparts.</p><p><b>METHODS: </b>We pooled data from 28,867 participants free of stroke and dementia (mean, SD: age 61 [10.7] years at the first cognitive assessment, 55% female, 24% Black, and 29% obese) from 6 cohorts. The primary outcome was the annual change in global cognition. We performed linear mixed-effects models with and without time-varying cumulative mean systolic blood pressure (SBP) and fasting plasma glucose (FPG). Global cognition was set to a t-score metric (mean 50, SD 10) at a participant's first cognitive assessment; a 1-point difference represents a 0.1 SD difference in global cognition across the 6 cohorts. The median follow-up was 6.5 years (25th percentile, 75th percentile: 5.03, 20.15).</p><p><b>RESULTS: </b>Obese participants had lower baseline global cognition than normal-weight participants (difference in intercepts, -0.36 [95% CI, -0.46 to -0.17]; < 0.001). This difference in baseline global cognition was attenuated but was borderline significant after accounting for SBP and FPG (adjusted differences in intercepts, -0.19 [95% CI, -0.39 to 0.002]; = 0.05). There was no difference in the rate of decline in global cognition between obese and normal-weight participants (difference in slope, 0.009 points/year [95% CI, -0.009 to 0.03]; = 0.32). After accounting for SBP and FPG, obese participants had a slower decline in global cognition (adjusted difference in slope, 0.03 points/year slower [95% CI, 0.01 to 0.05]; < 0.001). There was no evidence that race modified the association between body mass index and global cognitive decline ( = 0.34).</p><p><b>DISCUSSION: </b>These results suggest that obesity is associated with lower initial cognitive scores and may potentially attenuate declines in cognition after accounting for BP and FPG.</p> |
| DOI | 10.1212/WNL.0000000000201367 |
| Alternate Journal | Neurology |
| PubMed ID | 36257719 |
| PubMed Central ID | PMC9841449 |
| Grant List | R01 AG054069 / AG / NIA NIH HHS / United States R01 HL127659 / HL / NHLBI NIH HHS / United States UL1 TR001420 / TR / NCATS NIH HHS / United States UL1 TR001079 / TR / NCATS NIH HHS / United States UL1 TR000040 / TR / NCATS NIH HHS / United States N01HC95169 / HL / NHLBI NIH HHS / United States N01HC95168 / HL / NHLBI NIH HHS / United States N01HC95167 / HL / NHLBI NIH HHS / United States N01HC95166 / HL / NHLBI NIH HHS / United States N01HC95165 / HL / NHLBI NIH HHS / United States 75N92020D00007 / HL / NHLBI NIH HHS / United States N01HC95164 / HL / NHLBI NIH HHS / United States 75N92020D00004 / HL / NHLBI NIH HHS / United States N01HC95163 / HL / NHLBI NIH HHS / United States 75N92020D00006 / HL / NHLBI NIH HHS / United States N01HC95162 / HL / NHLBI NIH HHS / United States 75N92020D00003 / HL / NHLBI NIH HHS / United States N01HC95161 / HL / NHLBI NIH HHS / United States 75N92020D00002 / HL / NHLBI NIH HHS / United States N01HC95160 / HL / NHLBI NIH HHS / United States 75N92020D00005 / HL / NHLBI NIH HHS / United States N01HC95159 / HL / NHLBI NIH HHS / United States HHSN268201500003I / HL / NHLBI NIH HHS / United States 75N92020D00001 / HL / NHLBI NIH HHS / United States R01 NS029993 / NS / NINDS NIH HHS / United States HHSN268201500001C / HL / NHLBI NIH HHS / United States R01 AG023629 / AG / NIA NIH HHS / United States U01 HL130114 / HL / NHLBI NIH HHS / United States U01 HL080295 / HL / NHLBI NIH HHS / United States 75N92021D00006 / HL / NHLBI NIH HHS / United States N01HC85086 / HL / NHLBI NIH HHS / United States N01HC85083 / HL / NHLBI NIH HHS / United States N01HC85082 / HL / NHLBI NIH HHS / United States N01HC85081 / HL / NHLBI NIH HHS / United States N01HC85080 / HL / NHLBI NIH HHS / United States N01HC85079 / HL / NHLBI NIH HHS / United States N01HC55222 / HL / NHLBI NIH HHS / United States HHSN268201800001C / HL / NHLBI NIH HHS / United States HHSN268200800007C / HL / NHLBI NIH HHS / United States HHSN268201200036C / HL / NHLBI NIH HHS / United States HHSN268201800004I / HL / NHLBI NIH HHS / United States HHSN268201800006I / HL / NHLBI NIH HHS / United States HHSN268201800003I / HL / NHLBI NIH HHS / United States HHSN268201800007I / HL / NHLBI NIH HHS / United States HHSN268201800005I / HL / NHLBI NIH HHS / United States R01 AG040282 / AG / NIA NIH HHS / United States U01 HL096917 / HL / NHLBI NIH HHS / United States U01 HL096902 / HL / NHLBI NIH HHS / United States U01 HL096899 / HL / NHLBI NIH HHS / United States U01 HL096814 / HL / NHLBI NIH HHS / United States U01 HL096812 / HL / NHLBI NIH HHS / United States HHSN268201700004I / HL / NHLBI NIH HHS / United States HHSN268201700005I / HL / NHLBI NIH HHS / United States HHSN268201700003I / HL / NHLBI NIH HHS / United States HHSN268201700002I / HL / NHLBI NIH HHS / United States HHSN268201700001I / HL / NHLBI NIH HHS / United States P30 AG053760 / AG / NIA NIH HHS / United States K01 AG050723 / AG / NIA NIH HHS / United States K01 AG050699 / AG / NIA NIH HHS / United States P30 AG024824 / AG / NIA NIH HHS / United States R01 AG051827 / AG / NIA NIH HHS / United States R01 NS102715 / NS / NINDS NIH HHS / United States |
ePub date:
23/01