| Title | {A meta-analysis of genome-wide association studies identifies multiple longevity genes |
| Publication Type | Journal Article |
| Year of Publication | 2019 |
| Authors | Deelen, J, Evans, DS, Arking, DE, Tesi, N, Nygaard, M, Liu, X, Wojczynski, MK, Biggs, ML, van der Spek, A, Atzmon, G, Ware, EB, Sarnowski, C, Smith, AV, ä, I, Cordell, HJ, Dose, J, Amin, N, Arnold, AM, Ayers, KL, Barzilai, N, Becker, EJ, Beekman, M, é, H, Christensen, K, Christiansen, L, Collerton, JC, Cubaynes, S, Cummings, SR, Davies, K, Debrabant, B, Deleuze, JF, Duncan, R, Faul, JD, Franceschi, C, Galan, P, Gudnason, V, Harris, TB, Huisman, M, Hurme, MA, Jagger, C, Jansen, I, ä, M, nen, M, Karasik, D, Kardia, SLR, Kingston, A, Kirkwood, TBL, Launer, LJ, ki, T, Lieb, W, inen, LP, Martin-Ruiz, C, Min, J, Nebel, A, Newman, AB, Nie, C, Nohr, EA, Orwoll, ES, Perls, TT, Province, MA, Psaty, BM, Raitakari, OT, Reinders, MJT, Robine, JM, Rotter, JI, Sebastiani, P, Smith, J, rensen, TIA, Taylor, KD, Uitterlinden, AG, van der Flier, W, van der Lee, SJ, van Duijn, CM, van Heemst, D, Vaupel, JW, Weir, D, Ye, K, Zeng, Y, Zheng, W, Holstege, H, Kiel, DP, Lunetta, KL, Slagboom, PE, Murabito, JM |
| Journal | Nat Commun |
| Volume | 10 |
| Pagination | 3669 |
| Date Published | Aug |
| Abstract | 2) shows the opposite. Moreover, rs7676745, located near GPR78, associates with lower odds of surviving to the 90th percentile age. Gene-level association analysis reveals a role for tissue-specific expression of multiple genes in longevity. Finally, genetic correlation of the longevity GWA results with that of several disease-related phenotypes points to a shared genetic architecture between health and longevity. |
