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The associations of markers of endothelial dysfunction with hip fracture risk.
Wednesday,2023-04-05 13:46 America/Los_Angeles — ecterry
| Title | The associations of markers of endothelial dysfunction with hip fracture risk. |
| Publication Type | Journal Article |
| Year of Publication | 2023 |
| Authors | Barzilay, JI, Bůzková, P, Fink, HA, Cauley, JA, Carbone, L, Elam, R, Robbins, JA, Stein, P, Sheets, K, Jalal, D, Mukamal, KJ |
| Journal | Arch Osteoporos |
| Volume | 18 |
| Issue | 1 |
| Pagination | 39 |
| Date Published | 2023 Mar 02 |
| ISSN | 1862-3514 |
| Keywords | Aged, Forearm, Hip Fractures, Humans, Osteoporotic Fractures, Vascular Diseases |
| Abstract | <p><b>UNLABELLED: </b>Endothelial dysfunction underlies the development of atherosclerotic vascular disease, which in turn is associated with osteoporotic fractures. Here, we examined the association of two markers of endothelial dysfunction with incident hip fracture risk in older adults but found no statistically significant associations between them.</p><p><b>PURPOSE/INTRODUCTION: </b>Endothelial dysfunction underlies the development of atherosclerotic vascular disease. Vascular disease, in turn, is associated with the risk of osteoporotic fractures, such as hip fractures. Here, we examine whether two measures of endothelial dysfunction are related to hip fracture risk.</p><p><b>METHODS: </b>Participants for this study were 2792 individuals (mean age 78.6 years) who had flow-mediated dilation (FMD) measured after ischemia in the forearm and 2255 adults (mean age 73.3 years) with measured soluble intercellular adhesion molecule (siCAM) levels, a constitutive endothelial cell membrane protein associated with the initiation of atherosclerosis. Mean follow-up was 9.7 and 11.7 years, respectively. There were 375 and 265 incident hip fractures, respectively, in each group.</p><p><b>RESULTS: </b>In Cox proportional hazards models, there was no significant association between FMD response and incident hip fracture (HR per 1% higher FMD was 0.98 [0.93, 1.04]; p = 0.44). In exploratory analyses, when data were examined dichotomously, participants in the lowest 80% of FMD (≤ 4.5%) had an adjusted 1.29 (0.98, 1.68; p = 0.067) higher hazard of hip fracture compared to participants in the upper 20% of FMD change. There were no significant associations between siCAM and incident hip fracture whether examined as a continuous or dichotomized variable.</p><p><b>CONCLUSIONS: </b>Among older adults, two measures of endothelial dysfunction were not significantly associated with hip fracture risk. There was a trend for higher fracture risk with lower FMD.</p> |
| DOI | 10.1007/s11657-023-01226-w |
| Alternate Journal | Arch Osteoporos |
| PubMed ID | 36859726 |
| PubMed Central ID | 6487649 |
| Grant List | HHSN268201200036C / HL / NHLBI NIH HHS / United States HHSN268200800007C / HL / NHLBI NIH HHS / United States HHSN268201800001C / HL / NHLBI NIH HHS / United States N01HC55222 / HL / NHLBI NIH HHS / United States N01 HC085079 / HC / NHLBI NIH HHS / United States N01HC85080 / HL / NHLBI NIH HHS / United States N01HC85081 / HL / NHLBI NIH HHS / United States U01 HL080295 / HL / NHLBI NIH HHS / United States U01 HL130114 / HL / NHLBI NIH HHS / United States R01 AG023629 / AG / NIA NIH HHS / United States K24 AG065525 / AG / NIA NIH HHS / United States |
ePub date:
23/03