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Evaluating the use of blood pressure polygenic risk scores across race/ethnic background groups.

TitleEvaluating the use of blood pressure polygenic risk scores across race/ethnic background groups.
Publication TypeJournal Article
Year of Publication2023
AuthorsKurniansyah, N, Goodman, MO, Khan, AT, Wang, J, Feofanova, E, Bis, JC, Wiggins, KL, Huffman, JE, Kelly, T, Elfassy, T, Guo, X, Palmas, W, Lin, HJ, Hwang, S-J, Gao, Y, Young, K, Kinney, GL, Smith, JA, Yu, B, Liu, S, Wassertheil-Smoller, S, Manson, JAE, Zhu, X, Chen, Y-DI, Lee, I-T, C Gu, C, Lloyd-Jones, DM, Zöllner, S, Fornage, M, Kooperberg, C, Correa, A, Psaty, BM, Arnett, DK, Isasi, CR, Rich, SS, Kaplan, RC, Redline, S, Mitchell, BD, Franceschini, N, Levy, D, Rotter, JI, Morrison, AC, Sofer, T
JournalNat Commun
Date Published2023 Jun 02
KeywordsBlood Pressure, Ethnicity, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Male, Multifactorial Inheritance, Population Health, Risk Factors
Abstract<p>We assess performance and limitations of polygenic risk scores (PRSs) for multiple blood pressure (BP) phenotypes in diverse population groups. We compare "clumping-and-thresholding" (PRSice2) and LD-based (LDPred2) methods to construct PRSs from each of multiple GWAS, as well as multi-PRS approaches that sum PRSs with and without weights, including PRS-CSx. We use datasets from the MGB Biobank, TOPMed study, UK biobank, and from All of Us to train, assess, and validate PRSs in groups defined by self-reported race/ethnic background (Asian, Black, Hispanic/Latino, and White). For both SBP and DBP, the PRS-CSx based PRS, constructed as a weighted sum of PRSs developed from multiple independent GWAS, perform best across all race/ethnic backgrounds. Stratified analysis in All of Us shows that PRSs are better predictive of BP in females compared to males, individuals without obesity, and middle-aged (40-60 years) compared to older and younger individuals.</p>
Alternate JournalNat Commun
PubMed ID37268629
PubMed Central IDPMC10238525
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