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Evaluating the use of blood pressure polygenic risk scores across race/ethnic background groups.
Saturday,2023-06-17 13:58 America/Los_Angeles — ecterry
| Title | Evaluating the use of blood pressure polygenic risk scores across race/ethnic background groups. |
| Publication Type | Journal Article |
| Year of Publication | 2023 |
| Authors | Kurniansyah, N, Goodman, MO, Khan, AT, Wang, J, Feofanova, E, Bis, JC, Wiggins, KL, Huffman, JE, Kelly, T, Elfassy, T, Guo, X, Palmas, W, Lin, HJ, Hwang, S-J, Gao, Y, Young, K, Kinney, GL, Smith, JA, Yu, B, Liu, S, Wassertheil-Smoller, S, Manson, JAE, Zhu, X, Chen, Y-DI, Lee, I-T, C Gu, C, Lloyd-Jones, DM, Zöllner, S, Fornage, M, Kooperberg, C, Correa, A, Psaty, BM, Arnett, DK, Isasi, CR, Rich, SS, Kaplan, RC, Redline, S, Mitchell, BD, Franceschini, N, Levy, D, Rotter, JI, Morrison, AC, Sofer, T |
| Journal | Nat Commun |
| Volume | 14 |
| Issue | 1 |
| Pagination | 3202 |
| Date Published | 2023 Jun 02 |
| ISSN | 2041-1723 |
| Keywords | Blood Pressure, Ethnicity, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Male, Multifactorial Inheritance, Population Health, Risk Factors |
| Abstract | <p>We assess performance and limitations of polygenic risk scores (PRSs) for multiple blood pressure (BP) phenotypes in diverse population groups. We compare "clumping-and-thresholding" (PRSice2) and LD-based (LDPred2) methods to construct PRSs from each of multiple GWAS, as well as multi-PRS approaches that sum PRSs with and without weights, including PRS-CSx. We use datasets from the MGB Biobank, TOPMed study, UK biobank, and from All of Us to train, assess, and validate PRSs in groups defined by self-reported race/ethnic background (Asian, Black, Hispanic/Latino, and White). For both SBP and DBP, the PRS-CSx based PRS, constructed as a weighted sum of PRSs developed from multiple independent GWAS, perform best across all race/ethnic backgrounds. Stratified analysis in All of Us shows that PRSs are better predictive of BP in females compared to males, individuals without obesity, and middle-aged (40-60 years) compared to older and younger individuals.</p> |
| DOI | 10.1038/s41467-023-38990-9 |
| Alternate Journal | Nat Commun |
| PubMed ID | 37268629 |
| PubMed Central ID | PMC10238525 |
ePub date:
23/06