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Association of total insulin-like growth factor-I, insulin-like growth factor binding protein-1 (IGFBP-1), and IGFBP-3 levels with incident coronary events and ischemic stroke.
Tuesday,2012-11-06 12:08 America/Los_Angeles — eenright
| Title | Association of total insulin-like growth factor-I, insulin-like growth factor binding protein-1 (IGFBP-1), and IGFBP-3 levels with incident coronary events and ischemic stroke. |
| Publication Type | Journal Article |
| Year of Publication | 2007 |
| Authors | Kaplan, RC, McGinn, AP, Pollak, MN, Kuller, LH, Strickler, HD, Rohan, TE, Cappola, AR, Xue, XN, Psaty, BM |
| Journal | J Clin Endocrinol Metab |
| Volume | 92 |
| Issue | 4 |
| Pagination | 1319-25 |
| Date Published | 2007 Apr |
| ISSN | 0021-972X |
| Keywords | Aged, Cardiovascular Diseases, Case-Control Studies, Cohort Studies, Coronary Disease, Female, Humans, Insulin-Like Growth Factor Binding Protein 1, Insulin-Like Growth Factor Binding Protein 3, Insulin-Like Growth Factor I, Male, Multivariate Analysis, Risk Factors, Stroke |
| Abstract | <p><b>CONTEXT: </b>Prior observational studies have demonstrated that the GH/IGF axis is associated with cardiovascular disease. However, this association has not been extensively studied among older adults.</p><p><b>OBJECTIVE: </b>The objective of this study was to assess the association between levels of total IGF-I and IGF binding proteins (IGFBP-1, IGFBP-3) and risk of incident coronary events and ischemic stroke.</p><p><b>DESIGN AND PARTICIPANTS: </b>A case-cohort analysis was conducted among adults 65 yr and older in the Cardiovascular Health Study.</p><p><b>MAIN OUTCOME MEASURES: </b>A total of 534 coronary events [316 nonfatal myocardial infarctions (MIs), 48 fatal MIs, and 170 fatal coronary heart disease events] and 370 ischemic strokes were identified on follow-up. Comparison subjects were 1122 randomly selected participants from the Cardiovascular Health Study.</p><p><b>RESULTS: </b>Mean follow-up time was 6.7 yr for coronary events, 5.6 yr for strokes, and 9.3 yr for comparison subjects. Hazard ratios (95% confidence intervals) associated with baseline levels of total IGF-I and IGFBPs were estimated using multivariate adjusted Cox proportional hazards models. Neither IGF-I nor IGFBP-1 levels predicted risk of incident coronary events or stroke. IGFBP-3 had an inverse association with risk of coronary events [adjusted hazard ratio per sd=0.88 (0.78-1.00), P=0.05] but was not associated with stroke. Exploratory analyses suggested that low IGF-I and low IGFBP-3 levels were significantly associated with higher risk of nonfatal MI (P<0.05) but not with risk of fatal MI or fatal coronary heart disease.</p><p><b>CONCLUSION: </b>Circulating levels of total IGF-I or IGFBP-1 were not associated with risk of total coronary events or ischemic stroke among older adults, whereas low IGFBP-3 level was associated with increased risk of incident coronary events.</p> |
| DOI | 10.1210/jc.2006-1631 |
| Alternate Journal | J Clin Endocrinol Metab |
| PubMed ID | 17264182 |
| Grant List | N01 HC-15103 / HC / NHLBI NIH HHS / United States N01-HC-35129 / HC / NHLBI NIH HHS / United States N01-HC-85079 / HC / NHLBI NIH HHS / United States N01-HC-85086 / HC / NHLBI NIH HHS / United States R01HL075516-01 / HL / NHLBI NIH HHS / United States |