You are here
{Serum NfL and GFAP are associated with incident dementia and dementia mortality in older adults: The cardiovascular health study
Thursday,2023-07-20 14:47 America/Los_Angeles — ecterry
| Title | {Serum NfL and GFAP are associated with incident dementia and dementia mortality in older adults: The cardiovascular health study |
| Publication Type | Journal Article |
| Year of Publication | 2023 |
| Authors | é, HT, Liu, X, Odden, MC, Moseholm, KF, Seshadri, S, Satizabal, CL, Lopez, OL, Bis, JC, é, L, Fohner, AE, Psaty, BM, Tracy, RP, Longstreth, WT, Jensen, MK, Mukamal, KJ |
| Journal | Alzheimers Dement |
| Date Published | Jul |
| Abstract | Circulating neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) have been independently associated with dementia risk. Their additive association, and their associations with dementia-specific mortality, have not been investigated.\ We associated serum NfL, GFAP, total tau ,and ubiquitin carboxyl-terminal hydrolase-L1, measured in 1712 dementia-free adults, with 19-year incident dementia and dementia-specific mortality risk, and with 3-year cognitive decline.\ 2.06 (1.60-2.67) and 9.22 (4.48-18.9). NfL was independently associated with accelerated cognitive decline.\ Circulating NfL and GFAP may, independently and jointly, provide useful clinical insight regarding dementia risk and prognosis. |
ePub date:
23/07