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Association of a blood-based aging biomarker index with death and chronic disease: Cardiovascular Health Study.
Tuesday,2023-08-15 13:28 America/Los_Angeles — ecterry
| Title | Association of a blood-based aging biomarker index with death and chronic disease: Cardiovascular Health Study. |
| Publication Type | Journal Article |
| Year of Publication | 2023 |
| Authors | Zhang, X, Sanders, JL, Boudreau, RM, Arnold, AM, Justice, JN, Espeland, MA, Kuchel, GA, Barzilai, N, Kuller, LH, Lopez, OL, Kritchevsky, SB, Newman, AB |
| Journal | J Gerontol A Biol Sci Med Sci |
| Date Published | 2023 Jul 19 |
| ISSN | 1758-535X |
| Abstract | <p><b>BACKGROUND: </b>A goal of gerontology is to discover phenotypes that reflect biological aging distinct from disease pathogenesis. Biomarkers that are strongly associated with mortality could be used to define such a phenotype. However, the relation of such an index with multiple chronic conditions warrants further exploration.</p><p><b>METHODS: </b>A Biomarker Index (BI) was constructed in the Cardiovascular Health Study (N=3197), with a mean age of 74 years. The BI incorporated circulating levels of new biomarkers, including insulin-like growth factor-1, interleukin-6, amino-terminal pro-B-type natriuretic peptide, cystatin-C, C-reactive protein, tumor necrosis factor-alpha soluble receptor 1, fasting insulin, and fasting glucose, and was built based on their relationships with mortality. Cox proportional hazards models predicting a composite of death and chronic disease involving cardiovascular disease, dementia, and cancer were calculated with 6 years of follow-up.</p><p><b>RESULTS: </b>The hazard ratio (HR, 95% CI) for the composite outcome of death or chronic disease per category of BI was 1.65 (1.52, 1.80) and 1.75 (1.58, 1.94) in women and men, respectively. The HR (95% CI) per 5 years of age was 1.57 (1.48, 1.67) and 1.55 (1.44, 1.67) in women and men, respectively. Moreover, BI could attenuate the effect of age on the composite outcome by 16.7% and 22.0% in women and men, respectively.</p><p><b>CONCLUSIONS: </b>BI was significantly and independently associated with a composite outcome of death and chronic disease, and attenuated the effect of age. The BI that is composed of plasma biomarkers may be a practical intermediate phenotype for interventions aiming to modify the course of aging.</p> |
| DOI | 10.1093/gerona/glad172 |
| Alternate Journal | J Gerontol A Biol Sci Med Sci |
| PubMed ID | 37464278 |
ePub date:
23/07