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n-3 Fatty Acid Biomarkers and Incident Type 2 Diabetes: An Individual Participant-Level Pooling Project of 20 Prospective Cohort Studies
Wednesday,2023-08-23 12:15 America/Los_Angeles — ecterry
| Title | n-3 Fatty Acid Biomarkers and Incident Type 2 Diabetes: An Individual Participant-Level Pooling Project of 20 Prospective Cohort Studies |
| Publication Type | Journal Article |
| Year of Publication | 2021 |
| Authors | Qian, F, Korat, AVArdisso, Imamura, F, Marklund, M, Tintle, N, Virtanen, JK, Zhou, X, Bassett, JK, Lai, H, Hirakawa, Y, Chien, KL, Wood, AC, Lankinen, M, Murphy, RA, Samieri, C, Pertiwi, K, de Mello, VD, Guan, W, Forouhi, NG, Wareham, N, Hu, ICFB, Riserus, U, Lind, L, Harris, WS, Shadyab, AH, Robinson, JG, Steffen, LM, Hodge, A, Giles, GG, Ninomiya, T, Uusitupa, M, Tuomilehto, J, m, J, Laakso, M, Siscovick, DS, Helmer, C, Geleijnse, JM, Wu, JHY, Fretts, A, Lemaitre, RN, Micha, R, Mozaffarian, D, Sun, Q |
| Journal | Diabetes Care |
| Volume | 44 |
| Pagination | 1133–1142 |
| Date Published | May |
| Abstract | -linolenic acid (ALA), eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and docosahexaenoic acid (DHA) with T2D risk through an individual participant-level pooled analysis.\ For our analysis we incorporated data from a global consortium of 20 prospective studies from 14 countries. We included 65,147 participants who had blood measurements of ALA, EPA, DPA, or DHA and were free of diabetes at baseline. De novo harmonized analyses were performed in each cohort following a prespecified protocol, and cohort-specific associations were pooled using inverse variance-weighted meta-analysis.\ 0.001). ALA was not associated with T2D (HR 0.97 [95% CI 0.92, 1.02]) per interquintile range. Associations were robust across prespecified subgroups as well as in sensitivity analyses.\ Higher circulating biomarkers of seafood-derived n-3 fatty acids, including EPA, DPA, DHA, and their sum, were associated with lower risk of T2D in a global consortium of prospective studies. The biomarker of plant-derived ALA was not significantly associated with T2D risk. |
ePub date:
21/05