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{Trans Fatty Acid Biomarkers and Incident Type 2 Diabetes: Pooled Analysis of 12 Prospective Cohort Studies in the Fatty Acids and Outcomes Research Consortium (FORCE)
Wednesday,2023-08-23 16:18 America/Los_Angeles — ecterry
| Title | {Trans Fatty Acid Biomarkers and Incident Type 2 Diabetes: Pooled Analysis of 12 Prospective Cohort Studies in the Fatty Acids and Outcomes Research Consortium (FORCE) |
| Publication Type | Journal Article |
| Year of Publication | 2022 |
| Authors | Lai, HTM, Imamura, F, Korat, AVA, Murphy, RA, Tintle, N, Bassett, JK, Chen, J, ger, J, Chien, KL, Senn, M, Wood, AC, Forouhi, NG, Schulze, MB, Harris, WS, Vasan, RS, Hu, F, Giles, GG, Hodge, A, Djousse, L, Brouwer, IA, Qian, F, Sun, Q, Wu, JHY, Marklund, M, Lemaitre, RN, Siscovick, DS, Fretts, AM, Shadyab, AH, Manson, JE, Howard, BV, Robinson, JG, Wallace, RB, Wareham, NJ, Chen, YI, Rotter, JI, Tsai, MY, Micha, R, Mozaffarian, D |
| Journal | Diabetes Care |
| Volume | 45 |
| Pagination | 854–863 |
| Date Published | Apr |
| Abstract | Trans fatty acids (TFAs) have harmful biologic effects that could increase the risk of type 2 diabetes (T2D), but evidence remains uncertain. We aimed to investigate the prospective associations of TFA biomarkers and T2D by conducting an individual participant-level pooled analysis.\ 18 years without prevalent diabetes. Each cohort conducted de novo harmonized analyses using a prespecified protocol, and findings were pooled using inverse-variance weighted meta-analysis. Heterogeneity was explored by prespecified between-study and within-study characteristics.\ 0.1).\ Circulating individual trans-18:2 TFA biomarkers were not associated with risk of T2D, while trans-16:1n-9, total trans-18:1, and total trans-18:2 were inversely associated. Findings may reflect the influence of mixed TFA sources (industrial vs. natural ruminant), a general decline in TFA exposure due to policy changes during this period, or the relatively limited range of TFA levels. |
ePub date:
22/04