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740 adults from 20 prospective cohort studies

Title740 adults from 20 prospective cohort studies
Publication TypeJournal Article
Year of Publication2017
AuthorsWu, JHY, Marklund, M, Imamura, F, Tintle, N, Korat, AVArdisso, de Goede, J, Zhou, X, Yang, WS, Otto, MC de Oliv, ger, J, Qureshi, W, Virtanen, JK, Bassett, JK, Frazier-Wood, AC, Lankinen, M, Murphy, RA, Rajaobelina, K, Del Gobbo, LC, Forouhi, NG, Luben, R, Khaw, KT, Wareham, N, Kalsbeek, A, Veenstra, J, Luo, J, Hu, FB, Lin, HJ, Siscovick, DS, Boeing, H, Chen, TA, Steffen, B, Steffen, LM, Hodge, A, Eriksdottir, G, Smith, AV, Gudnason, V, Harris, TB, Brouwer, IA, Berr, C, Helmer, C, Samieri, C, Laakso, M, Tsai, MY, Giles, GG, Nurmi, T, Wagenknecht, L, Schulze, MB, Lemaitre, RN, Chien, KL, Soedamah-Muthu, SS, Geleijnse, JM, Sun, Q, Harris, WS, Lind, L, v, J, Riserus, U, Micha, R, Mozaffarian, D
JournalLancet Diabetes Endocrinol
Date PublishedDec
AbstractThe metabolic effects of omega-6 polyunsaturated fatty acids (PUFAs) remain contentious, and little evidence is available regarding their potential role in primary prevention of type 2 diabetes. We aimed to assess the associations of linoleic acid and arachidonic acid biomarkers with incident type 2 diabetes.\ We did a pooled analysis of new, harmonised, individual-level analyses for the biomarkers linoleic acid and its metabolite arachidonic acid and incident type 2 diabetes. We analysed data from 20 prospective cohort studies from ten countries (Iceland, the Netherlands, the USA, Taiwan, the UK, Germany, Finland, Australia, Sweden, and France), with biomarkers sampled between 1970 and 2010. Participants included in the analyses were aged 18 years or older and had data available for linoleic acid and arachidonic acid biomarkers at baseline. We excluded participants with type 2 diabetes at baseline. The main outcome was the association between omega-6 PUFA biomarkers and incident type 2 diabetes. We assessed the relative risk of type 2 diabetes prospectively for each cohort and lipid compartment separately using a prespecified analytic plan for exposures, covariates, effect modifiers, and analysis, and the findings were then pooled using inverse-variance weighted meta-analysis.\ 13).\ Findings suggest that linoleic acid has long-term benefits for the prevention of type 2 diabetes and that arachidonic acid is not harmful.\ Funders are shown in the appendix.
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