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Association of Immune Cell Subsets with Incident Hip Fracture: The Cardiovascular Health Study.
Wednesday,2023-09-13 20:29 America/Los_Angeles — ecterry
| Title | Association of Immune Cell Subsets with Incident Hip Fracture: The Cardiovascular Health Study. |
| Publication Type | Journal Article |
| Year of Publication | 2023 |
| Authors | Elam, RE, Bůzková, P, Delaney, JAC, Fink, HA, Barzilay, JI, Carbone, LD, Saha, R, Robbins, JA, Mukamal, KJ, Valderrábano, RJ, Psaty, BM, Tracy, RP, Olson, NC, Huber, SA, Doyle, MF, Landay, AL, Cauley, JA |
| Journal | Calcif Tissue Int |
| Date Published | 2023 Aug 31 |
| ISSN | 1432-0827 |
| Abstract | <p>In this study, we aimed to evaluate the association of innate and adaptive immune cell subsets in peripheral blood mononuclear cells (PBMCs) with hip fracture. To conduct this study, we used data from the Cardiovascular Health Study (CHS), a U.S. multicenter observational cohort of community-dwelling men and women aged ≥ 65 years. Twenty-five immune cell phenotypes were measured by flow cytometry from cryopreserved PBMCs of CHS participants collected in 1998-1999. The natural killer (NK), γδ T, T helper 17 (Th17), and differentiated/senescent CD4CD28 T cell subsets were pre-specified as primary subsets of interest. Hip fracture incidence was assessed prospectively by review of hospitalization records. Multivariable Cox hazard models evaluated associations of immune cell phenotypes with incident hip fracture in sex-stratified and combined analyses. Among 1928 persons, 259 hip fractures occurred over a median 9.7 years of follow-up. In women, NK cells were inversely associated with hip fracture [hazard ratio (HR) 0.77, 95% confidence interval (CI) 0.60-0.99 per one standard deviation higher value] and Th17 cells were positively associated with hip fracture [HR 1.18, 95% CI 1.01-1.39]. In men, γδ T cells were inversely associated with hip fracture [HR 0.60, 95% CI 0.37-0.98]. None of the measured immune cell phenotypes were significantly associated with hip fracture incidence in combined analyses. In this large prospective cohort of older adults, potentially important sex differences in the associations of immune cell phenotypes and hip fracture were identified. However, immune cell phenotypes had no association with hip fracture in analyses combining men and women.</p> |
| DOI | 10.1007/s00223-023-01126-8 |
| Alternate Journal | Calcif Tissue Int |
| PubMed ID | 37650930 |
| PubMed Central ID | 5895643 |
| Grant List | N01HC85081 / HL / NHLBI NIH HHS / United States N01HC55222 / HL / NHLBI NIH HHS / United States 75N92021D00006 / NS / NINDS NIH HHS / United States R01AG023629 / AG / NIA NIH HHS / United States N01HC85080 / HL / NHLBI NIH HHS / United States N01HC85086 / NS / NINDS NIH HHS / United States HHSN268201800001C / HL / NHLBI NIH HHS / United States grants U01HL080295 / NS / NINDS NIH HHS / United States N01HC55222 / NS / NINDS NIH HHS / United States N01HC85079 / NS / NINDS NIH HHS / United States grants U01HL080295 / HL / NHLBI NIH HHS / United States N01HC85080 / NS / NINDS NIH HHS / United States N01HC85083 / NS / NINDS NIH HHS / United States N01HC85083 / HL / NHLBI NIH HHS / United States contracts HHSN268201200036C / NS / NINDS NIH HHS / United States N01HC85082 / HL / NHLBI NIH HHS / United States R01HL135625 / HL / NHLBI NIH HHS / United States U01HL130114 / NS / NINDS NIH HHS / United States HHSN268200800007C / NS / NINDS NIH HHS / United States R01 HL120854 / HL / NHLBI NIH HHS / United States N01HC85082 / NS / NINDS NIH HHS / United States HHSN268201800001C / NS / NINDS NIH HHS / United States R01HL120854 / HL / NHLBI NIH HHS / United States HHSN268200800007C / HL / NHLBI NIH HHS / United States contracts HHSN268201200036C / HL / NHLBI NIH HHS / United States 75N92021D00006 / HL / NHLBI NIH HHS / United States U01HL130114 / HL / NHLBI NIH HHS / United States N01HC85081 / NS / NINDS NIH HHS / United States N01HC85086 / HL / NHLBI NIH HHS / United States N01HC85079 / HL / NHLBI NIH HHS / United States |
ePub date:
23/08