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Neighborhood greenspace and neighborhood income associated with white matter grade worsening: Cardiovascular Health Study.
Tuesday,2023-12-05 14:18 America/Los_Angeles — ecterry
| Title | Neighborhood greenspace and neighborhood income associated with white matter grade worsening: Cardiovascular Health Study. |
| Publication Type | Journal Article |
| Year of Publication | 2023 |
| Authors | Besser, LM, Lovasi, GS, Zambrano, JJimenez, Camacho, S, Dhanekula, D, Michael, YL, Garg, P, Hirsch, JA, Siscovick, D, Hurvitz, PM, Biggs, ML, Galvin, JE, Bartz, TM, Longstreth, WT |
| Journal | Alzheimers Dement (Amst) |
| Volume | 15 |
| Issue | 4 |
| Pagination | e12484 |
| Date Published | 2023 Oct-Dec |
| ISSN | 2352-8729 |
| Abstract | <p><b>INTRODUCTION: </b>We examined whether a combined measure of neighborhood greenspace and neighborhood median income was associated with white matter hyperintensity (WMH) and ventricle size changes.</p><p><b>METHODS: </b>The sample included 1260 cognitively normal ≥ 65-year-olds with two magnetic resonance images (MRI; ≈ 5 years apart). WMH and ventricular size were graded from 0 (least) to 9 (most) abnormal (worsening = increase of ≥1 grade from initial to follow-up MRI scans). The four-category neighborhood greenspace-income measure was based on median neighborhood greenspace and income values at initial MRI. Multivariable logistic regression tested associations between neighborhood greenspace-income and MRI measures (worsening vs. not).</p><p><b>RESULTS: </b>White matter grade worsening was more likely for those in lower greenspace-lower income neighborhoods than higher greenspace-higher income neighborhoods (odds ratio = 1.73; 95% confidence interval = 1.19-2.51).</p><p><b>DISCUSSION: </b>The combination of lower neighborhood income and lower greenspace may be a risk factor for worsening white matter grade on MRI. However, findings need to be replicated in more diverse cohorts.</p><p><b>HIGHLIGHTS: </b>Population-based cohort of older adults (≥ 65 years) with greenspace and MRI dataCombined measure of neighborhood greenspace and neighborhood income at initial MRIMRI outcomes included white matter hyperintensities (WMH) and ventricular sizeLongitudinal change in MRI outcomes measured approximately 5 years apartWorsening WMH over time more likely for lower greenspace-lower income neighborhoods.</p> |
| DOI | 10.1002/dad2.12484 |
| Alternate Journal | Alzheimers Dement (Amst) |
| PubMed ID | 37885920 |
| PubMed Central ID | PMC10598801 |
ePub date:
23/10