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{Polygenic burden of short tandem repeat expansions promote risk for Alzheimer's disease
Thursday,2024-02-01 21:34 America/Los_Angeles — ecterry
| Title | {Polygenic burden of short tandem repeat expansions promote risk for Alzheimer's disease |
| Publication Type | Journal Article |
| Year of Publication | 2023 |
| Authors | Guo, MH, Lee, WP, Vardarajan, B, Schellenberg, GD, Phillips-Cremins, J |
| Journal | medRxiv |
| Date Published | Nov |
| Abstract | 30 STR expansions had 3.62-fold higher odds of having AD and had more severe AD neuropathology. AD STR expansions were highly enriched within active promoters in post-mortem hippocampal brain tissues and particularly within SINE-VNTR-Alu (SVA) retrotransposons. Together, these results demonstrate that expanded STRs within active promoter regions of the genome promote risk of AD. |
ePub date:
23/11