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Focal atrophy and cerebrovascular disease increase dementia risk among cognitively normal older adults.
Tuesday,2012-11-06 12:08 America/Los_Angeles — eenright
| Title | Focal atrophy and cerebrovascular disease increase dementia risk among cognitively normal older adults. |
| Publication Type | Journal Article |
| Year of Publication | 2007 |
| Authors | Rosano, C, Aizenstein, HJ, Wu, M, Newman, AB, Becker, JT, Lopez, OL, Kuller, LH |
| Journal | J Neuroimaging |
| Volume | 17 |
| Issue | 2 |
| Pagination | 148-55 |
| Date Published | 2007 Apr |
| ISSN | 1051-2284 |
| Keywords | Aged, Alzheimer Disease, Analysis of Variance, Atrophy, Cerebrovascular Disorders, Cognition, Female, Humans, Logistic Models, Longitudinal Studies, Magnetic Resonance Imaging, Male, Risk Factors, Temporal Lobe, United States |
| Abstract | <p><b>BACKGROUND AND PURPOSE: </b>This study investigated the association of medial temporal lobe (MTL) atrophy and cerebrovascular disease (white matter hyperintensities [WMH], subclinical infarcts) with the risk of developing Alzheimer's disease (AD) among cognitively normal older adults.</p><p><b>METHODS: </b>Risk of developing AD was examined for 155 cognitively normal older adults (77.4 years, 60% women, 81% white). The MTL volumes and the presence of WMH and of subclinical infarcts were determined from brain magnetic resonance imaging (MRI) at the beginning of the study. Follow-up cognitive evaluations (average 4.3 years) identified those who developed AD.</p><p><b>RESULTS: </b>The presence of either MTL atrophy or subclinical infarcts was independently and significantly associated with a greater risk to develop AD (OR [95% CI]: 4.4 [1.5, 12.3] and 2.7 [1.0, 7.1], respectively). In addition, those participants with both MTL atrophy and at least one brain infarct had a 7-fold increase in the risk of developing AD (OR [95% CI]: 7.0 [1.5, 33.1]), compared to those who had neither of these conditions.</p><p><b>CONCLUSIONS: </b>In cognitively normal older adults, markers of neurodegeneration (as reflected by MTL atrophy) and of cerebrovascular disease (as reflected by infarcts on MRI) independently contribute to the risk to develop AD.</p> |
| DOI | 10.1111/j.1552-6569.2007.00093.x |
| Alternate Journal | J Neuroimaging |
| PubMed ID | 17441836 |
| Grant List | N01 HC-15103 / HC / NHLBI NIH HHS / United States N01-HC-35129 / HC / NHLBI NIH HHS / United States N01-HC-85079 / HC / NHLBI NIH HHS / United States N01-HC-85086 / HC / NHLBI NIH HHS / United States R01AG015928 / AG / NIA NIH HHS / United States R01AG020098 / AG / NIA NIH HHS / United States T32 AG00181-11 / AG / NIA NIH HHS / United States |