| Title | {Multi-trait analysis characterizes the genetics of thyroid function and identifies causal associations with clinical implications |
| Publication Type | Journal Article |
| Year of Publication | 2024 |
| Authors | Sterenborg, RBTM, Steinbrenner, I, Li, Y, Bujnis, MN, Naito, T, Marouli, E, Galesloot, TE, Babajide, O, Andreasen, L, Astrup, A, svold, BO, Bandinelli, S, Beekman, M, Beilby, JP, Bork-Jensen, J, Boutin, T, Brody, JA, Brown, SJ, Brumpton, B, Campbell, PJ, Cappola, AR, Ceresini, G, Chaker, L, Chasman, DI, Concas, MP, R. de Almeida, C, Cross, SM, Cucca, F, Deary, IJ, Kjaergaard, AD, Tcheugui, JBEchouff, Ellervik, C, Eriksson, JG, Ferrucci, L, Freudenberg, J, Fuchsberger, C, Gieger, C, Giulianini, F, gele, M, Graham, SE, Grarup, N, ä, I, Hansen, T, Harding, BN, Harris, SE, ø, S, Hayward, C, Hui, J, Ittermann, T, Jukema, JW, Kajantie, E, Kanters, JK, rhus, LL, Kiemeney, LALM, Kloppenburg, M, hnel, B, Lahti, J, Langenberg, C, Lapauw, B, Leese, G, Li, S, Liewald, DCM, Linneberg, A, Lominchar, JVT, Luan, J, Martin, NG, Matana, A, Meima, ME, Meitinger, T, Meulenbelt, I, Mitchell, BD, llehave, LT, Mora, S, Naitza, S, Nauck, M, Netea-Maier, RT, Noordam, R, Nursyifa, C, Okada, Y, Onano, S, Papadopoulou, A, Palmer, CNA, Pattaro, C, Pedersen, O, Peters, A, Pietzner, M, ek, O, Pramstaller, PP, Psaty, BM, Punda, A, Ray, D, Redmond, P, Richards, JB, Ridker, PM, Russ, TC, Ryan, KA, Olesen, MS, Schultheiss, UT, Selvin, E, Siddiqui, MK, Sidore, C, Slagboom, PE, rensen, TIA, Soto-Pedre, E, Spector, TD, Spedicati, B, Srinivasan, S, Starr, JM, Stott, DJ, Tanaka, T, Torlak, V, Trompet, S, Tuhkanen, J, Uitterlinden, AG, van den Akker, EB, van den Eynde, T, van der Klauw, MM, van Heemst, D, Verroken, C, Visser, WE, Vojinovic, D, lzke, H, Waldenberger, M, Walsh, JP, Wareham, NJ, Weiss, S, Willer, CJ, Wilson, SG, Wolffenbuttel, BHR, Wouters, HJCM, Wright, MJ, Yang, Q, Zemunik, T, Zhou, W, Zhu, G, llner, S, Smit, JWA, Peeters, RP, ttgen, A, Teumer, A, Medici, M |
| Journal | Nat Commun |
| Volume | 15 |
| Pagination | 888 |
| Date Published | Jan |
| Abstract | T3, whereas the FT4 associations represent the thyroid hormone metabolism. Polygenic risk score and Mendelian randomization analyses showed the effects of genetically determined variation in thyroid function on various clinical outcomes, including cardiovascular risk factors and diseases, autoimmune diseases, and cancer. In conclusion, our results improve the understanding of thyroid hormone physiology and highlight the pleiotropic effects of thyroid function on various diseases. |
