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Association of serum levels of phenylalanine and tyrosine with hip fractures and frailty in older adults: The cardiovascular health study.
Thursday,2024-07-11 10:08 America/Los_Angeles — ecterry
| Title | Association of serum levels of phenylalanine and tyrosine with hip fractures and frailty in older adults: The cardiovascular health study. |
| Publication Type | Journal Article |
| Year of Publication | 2024 |
| Authors | Carbone, L, Bůzková, P, Robbins, JA, Fink, HA, Barzilay, JI, Elam, RE, Isales, C |
| Journal | Arch Osteoporos |
| Volume | 19 |
| Issue | 1 |
| Pagination | 51 |
| Date Published | 2024 Jun 20 |
| ISSN | 1862-3514 |
| Keywords | Aged, Aged, 80 and over, Cross-Sectional Studies, Female, Frail Elderly, Frailty, Hip Fractures, Humans, Male, Phenylalanine, Risk Factors, Tyrosine |
| Abstract | <p><b>UNLABELLED: </b>This study examined if the amino acids phenylalanine or tyrosine contribute to risk of hip fracture or frailty in older adults. We determined that neither phenylalanine nor tyrosine are important predictors of hip fracture or frailty. We suggest advice on protein intake for skeletal health consider specific amino acid composition.</p><p><b>PURPOSE: </b>Protein is essential for skeletal health, but the specific amino acid compositions of protein may have differential associations with fracture risk. The aim of this study was to determine the association of serum levels of the aromatic amino acids phenylalanine and tyrosine with risk for incident hip fractures over twelve years of follow-up and cross sectional associations with frailty.</p><p><b>METHODS: </b>We included 131 older men and women from the Cardiovascular Health Study (CHS) who sustained a hip fracture over twelve years of follow-up and 131 men and women without an incident hip fracture over this same period of time. 42% of this cohort were men and 95% were Caucasian. Weighted multivariable Cox hazards molecules were used to estimate the hazard ratios (HR) and 95% confidence intervals (CI) of incident hip fracture associated with a one standard deviation (SD) higher serum level of phenylalanine or tyrosine. Relative risk regression was used to determine the cross-sectional association of these amino acids with Freid's frailty index.</p><p><b>RESULTS: </b>Neither serum levels of phenylalanine (HR 0.85 (95% CI 0.62-1.16) or tyrosine (HR 0.82 (95% CI 0.62-1.1) were significantly associated with incident hip fractures or cross sectionally with frailty (frail compared with prefrail/not frail) (HR 0.92 (95% CI 0.48-1.76) and HR (0.86 (95% CI 0.46-1.61) respectively.</p><p><b>CONCLUSION: </b>Phenylalanine and tyrosine are not significant contributors to hip fractures or frailty in older men and women.</p> |
| DOI | 10.1007/s11657-024-01408-0 |
| Alternate Journal | Arch Osteoporos |
| PubMed ID | 38898169 |
| PubMed Central ID | 1388220 |
| Grant List | HHSN268201200036C / NS / NINDS NIH HHS / United States HHSN268200800007C / NS / NINDS NIH HHS / United States HHSN268201800001C / NS / NINDS NIH HHS / United States N01HC55222 / NS / NINDS NIH HHS / United States N01HC85079 / NS / NINDS NIH HHS / United States N01HC85080 / NS / NINDS NIH HHS / United States N01HC85081 / NS / NINDS NIH HHS / United States N01HC85082 / NS / NINDS NIH HHS / United States N01HC85083 / NS / NINDS NIH HHS / United States N01HC85086 / NS / NINDS NIH HHS / United States 75N92021D00006 / NS / NINDS NIH HHS / United States U01HL080295 / NS / NINDS NIH HHS / United States U01HL130114 / NS / NINDS NIH HHS / United States U01HL080295 / HL / NHLBI NIH HHS / United States U01HL130114 / HL / NHLBI NIH HHS / United States R01AG023629 / AG / NIA NIH HHS / United States |
ePub date:
24/06