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Relationship of uric acid with progression of kidney disease.
Tuesday,2012-11-06 12:08 America/Los_Angeles — eenright
| Title | Relationship of uric acid with progression of kidney disease. |
| Publication Type | Journal Article |
| Year of Publication | 2007 |
| Authors | Chonchol, M, Shlipak, MG, Katz, R, Sarnak, MJ, Newman, AB, Siscovick, DS, Kestenbaum, B, Carney, JKirk, Fried, LF |
| Journal | Am J Kidney Dis |
| Volume | 50 |
| Issue | 2 |
| Pagination | 239-47 |
| Date Published | 2007 Aug |
| ISSN | 1523-6838 |
| Keywords | Aged, Aged, 80 and over, Cohort Studies, Cross-Sectional Studies, Disease Progression, Female, Glomerular Filtration Rate, Humans, Kidney Diseases, Male, Prospective Studies, Uric Acid |
| Abstract | <p><b>BACKGROUND: </b>Uric acid levels are increased in patients with kidney dysfunction. We tested the hypothesis that uric acid may be associated with kidney disease progression.</p><p><b>STUDY DESIGN: </b>Cohort study.</p><p><b>SETTING & PARTICIPANTS: </b>5,808 participants of the Cardiovascular Health Study.</p><p><b>PREDICTOR: </b>Uric acid levels.</p><p><b>OUTCOMES & MEASUREMENTS: </b>Kidney disease progression was defined as a decrease in estimated glomerular filtration rate (GFR) of 3 mL/min/1.73 m(2) per year or greater (>or=0.05 mL/s) and as incident chronic kidney disease (CKD). Measures of kidney function were estimated GFR using the Modification of Diet in Renal Disease Study equation.</p><p><b>RESULTS: </b>Higher quintiles of uric acid levels were associated with greater prevalences of estimated GFR less than 60 mL/min/1.73 m(2) (<1.00 mL/s) of 7%, 14%, 12%, 25%, and 42% for quintiles 1 (<or=4.41 mg/dL [<or=262 micromol/L]), 2 (4.41 to 5.20 mg/dL [262 to 309 micromol/L]), 3 (5.21 to 5.90 mg/dL [310 to 351 micromol/L]), 4 (5.91 to 6.90 mg/dL [352 to 410 micromol/L]), and 5 (>6.90 mg/dL [>410 micromol/L]), respectively. In comparison, there was only a modest, but significant, association between quintiles of uric acid levels and progression of kidney function decrease, with adjusted odds ratios of 1.0, 0.88 (95% confidence interval [CI], 0.64 to 1.21), 1.23 (95% CI, 0.87 to 1.75), 1.47 (95% CI, 1.04 to 2.07), and 1.49 (95% CI, 1.00 to 2.22) for quintiles 1 through 5, respectively. No significant association was found between uric acid level and incident CKD (adjusted odds ratio, 1.00; 95% CI, 0.89 to 1.14).</p><p><b>LIMITATIONS: </b>Measurements of albuminuria were not available.</p><p><b>CONCLUSIONS: </b>Uric acid levels are associated strongly with prevalent CKD. In comparison, greater uric acid levels had a significant, but much weaker, association with progression of kidney disease.</p> |
| DOI | 10.1053/j.ajkd.2007.05.013 |
| Alternate Journal | Am J Kidney Dis |
| PubMed ID | 17660025 |
| Grant List | N01-HC-15103 / HC / NHLBI NIH HHS / United States N01-HC-35129 / HC / NHLBI NIH HHS / United States N01-HC-45133 / HC / NHLBI NIH HHS / United States N01-HC-75150 / HC / NHLBI NIH HHS / United States N01-HC-85079 / HC / NHLBI NIH HHS / United States N01-HC-85080 / HC / NHLBI NIH HHS / United States N01-HC-85081 / HC / NHLBI NIH HHS / United States N01-HC-85082 / HC / NHLBI NIH HHS / United States N01-HC-85083 / HC / NHLBI NIH HHS / United States N01-HC-85084 / HC / NHLBI NIH HHS / United States N01-HC-85085 / HC / NHLBI NIH HHS / United States N01-HC-85086 / HC / NHLBI NIH HHS / United States R01 AG027002 / AG / NIA NIH HHS / United States |