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Associations between toxicity-weighted concentrations and dementia risk: Results from the Cardiovascular Health Cognition Study.
Monday,2024-09-16 10:39 America/Los_Angeles — ecterry
| Title | Associations between toxicity-weighted concentrations and dementia risk: Results from the Cardiovascular Health Cognition Study. |
| Publication Type | Journal Article |
| Year of Publication | 2024 |
| Authors | Crane, BM, Moored, KD, Donahue, PT, Corrigan, AE, Curriero, FC, Shields, TM, Desjardins, MR, Richards, EA, Rosso, AL, Lovasi, GS, Odden, MC, Lopez, OL, Biggs, MLou, Newman, AB, Andrews, RM, Carlson, MC |
| Journal | Sci Total Environ |
| Volume | 945 |
| Pagination | 173706 |
| Date Published | 2024 Oct 01 |
| ISSN | 1879-1026 |
| Keywords | Aged, Aged, 80 and over, Air Pollutants, Air Pollution, Dementia, Environmental Exposure, Female, Humans, Male, Risk Factors |
| Abstract | <p><b>BACKGROUND: </b>Air pollution is a modifiable risk factor for dementia. Yet, studies on specific sources of air pollution (i.e., toxic chemical emissions from industrial facilities) and dementia risk are scarce. We examined associations between toxicity-weighted concentrations of industrial pollution and dementia outcomes among a large, multi-site cohort of older adults.</p><p><b>METHODS: </b>Participants (n = 2770) were ≥ 65 years old (Mean = 75.3, SD = 5.1 years) from the Cardiovascular Health Cognition Study (1992-1999). Toxicity-weighted concentrations were estimated using the Risk Screening Environmental Indicator (RSEI) model which incorporates total reported chemical emissions with toxicity, fate, and transport models. Estimates were aggregated to participants' baseline census tract, averaged across 1988-1992, and log2-transformed. Dementia status was clinically adjudicated in 1998-1999 and categorized by subtype (Alzheimer's, vascular, mixed). We assessed whether RSEI-estimated toxicity-weighted concentrations were associated with 1) odds of prevalent dementia and 2) incident dementia risk by subtype.</p><p><b>RESULTS: </b>After adjusting for individual and census-tract level covariates, a doubling in toxicity-weighted concentrations was associated with 9 % higher odds of prevalent dementia (OR = 1.09, 95 % CI: 1.00, 1.19). In discrete-time survival models, each doubling in toxicity-weighted concentrations was associated with a 16 % greater hazard of vascular dementia (HR = 1.16, 95 % CI: 1.01, 1.34) but was not significantly associated with all-cause, Alzheimer's disease, or mixed dementia (p's > 0.05).</p><p><b>DISCUSSION: </b>Living in regions with higher toxicity-weighted concentrations was associated with higher odds of prevalent dementia and a higher risk of incident vascular dementia in this large, community-based cohort of older adults. These findings support the need for additional studies to examine whether toxic chemical emissions from industrial and federal facilities may be a modifiable target for dementia prevention.</p> |
| DOI | 10.1016/j.scitotenv.2024.173706 |
| Alternate Journal | Sci Total Environ |
| PubMed ID | 38866169 |
| PubMed Central ID | PMC11262620 |
| Grant List | R01 AG055404 / AG / NIA NIH HHS / United States T32 AG000247 / AG / NIA NIH HHS / United States U01 HL130114 / HL / NHLBI NIH HHS / United States HHSN268200800007C / HL / NHLBI NIH HHS / United States N01HC55222 / HL / NHLBI NIH HHS / United States N01HC85086 / HL / NHLBI NIH HHS / United States R01 AG049970 / AG / NIA NIH HHS / United States N01HC85083 / HL / NHLBI NIH HHS / United States N01HC85080 / HL / NHLBI NIH HHS / United States N01HC85081 / HL / NHLBI NIH HHS / United States T32 AG027668 / AG / NIA NIH HHS / United States U01 HL080295 / HL / NHLBI NIH HHS / United States HHSN268201200036C / HL / NHLBI NIH HHS / United States HHSN268201800001C / HL / NHLBI NIH HHS / United States 75N92021D00006 / HL / NHLBI NIH HHS / United States N01HC85082 / HL / NHLBI NIH HHS / United States N01HC85079 / HL / NHLBI NIH HHS / United States R01 AG023629 / AG / NIA NIH HHS / United States |
ePub date:
24/10