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Circulating sphingolipids in relation to cognitive decline and incident dementia: The Cardiovascular Health Study.
Tuesday,2024-09-17 13:07 America/Los_Angeles — ecterry
| Title | Circulating sphingolipids in relation to cognitive decline and incident dementia: The Cardiovascular Health Study. |
| Publication Type | Journal Article |
| Year of Publication | 2024 |
| Authors | Moseholm, KF, Cronjé, HT, Koch, M, Fitzpatrick, AL, Lopez, OL, Otto, MC de Olive, Longstreth, WT, Hoofnagle, AN, Mukamal, KJ, Lemaitre, RN, Jensen, MK |
| Journal | Alzheimers Dement (Amst) |
| Volume | 16 |
| Issue | 3 |
| Pagination | e12623 |
| Date Published | 2024 Jul-Sep |
| ISSN | 2352-8729 |
| Abstract | <p><b>INTRODUCTION: </b>Whether circulating levels of sphingolipids are prospectively associated with cognitive decline and dementia risk is uncertain.</p><p><b>METHODS: </b>We measured 14 sphingolipid species in plasma samples from 4488 participants (mean age 76.2 years; 40% male; and 25% apolipoprotein E ( ε4 allele carriers). Cognitive decline was assessed annually across 6 years using modified Mini-Mental State Examination (3MSE) and Digital Symbol Substitution Test (DSST). Additionally, a subset of 3050 participants were followed for clinically adjudicated dementia.</p><p><b>RESULTS: </b>Higher plasma levels of sphingomyelin-d18:1/16:0 (SM-16) were associated with a faster cognitive decline measured with 3MSE, in contrast, higher levels of sphingomyelin-d18:1/22:0 (SM-22) were associated with slower decline in cognition measured with DSST. In Cox regression, higher levels of SM-16 (hazard ration [HR] = 1.24 [95% confidence interval [CI]: 1.08-1.44]) and ceramide-d18:1/16:0 (Cer-16) (HR = 1.26 [95% CI: 1.10-1.45]) were associated with higher risk of incident dementia.</p><p><b>DISCUSSION: </b>Several sphingolipid species appear to be involved in cognitive decline and dementia risk.</p><p><b>HIGHLIGHTS: </b>Plasma levels of sphingolipids were associated with cognitive decline and dementia risk.Ceramides and sphingomyelins with palmitic acid were associated with faster annual cognitive decline and increased risk of dementia.The direction of association depended on the covalently bound saturated fatty acid chain length in analysis of cognitive decline.</p> |
| DOI | 10.1002/dad2.12623 |
| Alternate Journal | Alzheimers Dement (Amst) |
| PubMed ID | 39130802 |
| PubMed Central ID | PMC11310412 |
| Grant List | K01 AG066817 / AG / NIA NIH HHS / United States U01 HL080295 / HL / NHLBI NIH HHS / United States U01 HL130114 / HL / NHLBI NIH HHS / United States HHSN268200800007C / HL / NHLBI NIH HHS / United States N01HC55222 / HL / NHLBI NIH HHS / United States N01HC85086 / HL / NHLBI NIH HHS / United States P30 DK035816 / DK / NIDDK NIH HHS / United States N01HC85083 / HL / NHLBI NIH HHS / United States K24 AG065525 / AG / NIA NIH HHS / United States N01HC85080 / HL / NHLBI NIH HHS / United States HHSN268201200036C / HL / NHLBI NIH HHS / United States HHSN268201800001C / HL / NHLBI NIH HHS / United States 75N92021D00006 / HL / NHLBI NIH HHS / United States N01HC85082 / HL / NHLBI NIH HHS / United States N01HC85079 / HL / NHLBI NIH HHS / United States R01 AG023629 / AG / NIA NIH HHS / United States N01HC85081 / HL / NHLBI NIH HHS / United States R01 HL128575 / HL / NHLBI NIH HHS / United States |
ePub date:
24/08