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Alzheimer's Disease Sequencing Project Release 4 Whole Genome Sequencing Dataset
Tuesday,2025-02-11 14:27 America/Los_Angeles — ecterry
| Title | Alzheimer's Disease Sequencing Project Release 4 Whole Genome Sequencing Dataset |
| Publication Type | Journal Article |
| Year of Publication | 2024 |
| Authors | Leung, YY, Lee, WP, Kuzma, AB, Nicaretta, H, Valladares, O, Gangadharan, P, Qu, L, Zhao, Y, Ren, Y, Cheng, PL, Kuksa, PP, Wang, H, White, H, Katanic, Z, Bass, L, Saravanan, N, Greenfest-Allen, E, Kirsch, M, Cantwell, L, Iqbal, T, Wheeler, NR, Farrell, JJ, Zhu, C, Turner, SL, Gunasekaran, TI, Mena, PR, Jin, J, Carter, L, Zhang, X, Vardarajan, BN, Toga, A, Cuccaro, M, Hohman, TJ, Bush, WS, Naj, AC, Martin, E, Dalgard, C, Kunkle, BW, Farrer, LA, Mayeux, RP, Haines, JL, Pericak-Vance, MA, Schellenberg, GD, Wang, LS |
| Journal | medRxiv |
| Date Published | Dec |
| Abstract | The Alzheimer's Disease Sequencing Project (ADSP) is a national initiative to understand the genetic architecture of Alzheimer's Disease and Related Dementias (AD/ADRD) by sequencing whole genomes of affected participants and age-matched cognitive controls from diverse populations. The Genome Center for Alzheimer's Disease (GCAD) processed whole-genome sequencing data from 36,361 ADSP participants, including 35,014 genetically unique participants of which 45% are from non-European ancestry, across 17 cohorts in 14 countries in this fourth release (R4). This sequencing effort identified 387 million bi-allelic variants, 42 million short insertions/deletions, and 2.2 million structural variants. Annotations and quality control data are available for all variants and samples. Additionally, detailed phenotypes from 15,927 participants across 10 domains are also provided. A linkage disequilibrium panel was created using unrelated AD cases and controls. Researchers can access and analyze the genetic data via NIAGADS Data Sharing Service, the VariXam tool, or NIAGADS GenomicsDB. |
ePub date:
24/12