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Sleep macro-architecture and dementia risk in adults: Meta-analysis of 5 cohorts from the Sleep and Dementia Consortium.
Tuesday,2025-02-11 15:03 America/Los_Angeles — ecterry
| Title | Sleep macro-architecture and dementia risk in adults: Meta-analysis of 5 cohorts from the Sleep and Dementia Consortium. |
| Publication Type | Journal Article |
| Year of Publication | 2024 |
| Authors | Yiallourou, S, Baril, A-A, Wiedner, C, Misialek, JR, Kline, CE, Harrison, S, Cannon, E, Yang, Q, Bernal, R, Bisson, A, Himali, D, Cavuoto, M, Weihs, A, Beiser, A, Gottesman, RF, Leng, Y, Lopez, O, Lutsey, PL, Purcell, SM, Redline, S, Seshadri, S, Stone, KL, Yaffe, K, Ancoli-Israel, S, Xiao, Q, Vaou, EOkeanis, Himali, JJ, Pase, MP |
| Journal | medRxiv |
| Date Published | 2024 Nov 05 |
| Abstract | <p><b>STUDY OBJECTIVES: </b>Poor sleep may play a role in the risk of dementia. However, few studies have investigated the association between polysomnography (PSG)-derived sleep architecture and dementia incidence. We examined the relationship between sleep macro-architecture and dementia incidence across five US-based cohort studies from the Sleep and Dementia Consortium (SDC).</p><p><b>METHODS: </b>Percent of time spent in stages of sleep (N1, N2, N3, REM sleep), wake after sleep onset and sleep maintenance efficiency were derived from a single night home-based PSG. Dementia was ascertained in each cohort using its cohort-specific criteria. Each cohort performed Cox proportional hazard regressions for each sleep exposure and incident dementia, adjusting for age, sex, body mass index, anti-depressant use, sedative use, and status. Results were then pooled in random effects meta-analyses.</p><p><b>RESULTS: </b>The pooled sample comprised 4,657 participants (30% women) aged ≥60 years (mean age was 74 years at sleep assessment). There were 998 (21.4%) dementia cases (median follow-up time of 5 to 19 years). Pooled effects of the five cohorts showed no association between sleep architecture and incident dementia. When meta-analyses were restricted to the three cohorts which had dementia case ascertainment based on DSM-IV/V criteria (n=2,374), higher N3% was marginally associated with an increased risk of dementia (HR: 1.06; 95%CI: 1.00-1.12, per percent increase N3, p=0.050).</p><p><b>CONCLUSIONS: </b>There were no consistent associations between sleep macro-architecture measured and the risk of incident dementia. Implementing more nuanced sleep metrics remains an important next step for uncovering more about sleep-dementia associations.</p> |
| DOI | 10.1101/2024.11.05.24316677 |
| Alternate Journal | medRxiv |
| PubMed ID | 39802761 |
| PubMed Central ID | PMC11722510 |
| Grant List | RF1 AG059421 / AG / NIA NIH HHS / United States 75N92022D00004 / HL / NHLBI NIH HHS / United States U01 AG042168 / AG / NIA NIH HHS / United States R21 MD012738 / MD / NIMHD NIH HHS / United States N01HC85080 / HL / NHLBI NIH HHS / United States U01 HL096812 / HL / NHLBI NIH HHS / United States R01 NS017950 / NS / NINDS NIH HHS / United States UF1 NS125513 / NS / NINDS NIH HHS / United States R01 AG054076 / AG / NIA NIH HHS / United States R01 HL070848 / HL / NHLBI NIH HHS / United States R01 AG015928 / AG / NIA NIH HHS / United States 75N92022D00002 / HL / NHLBI NIH HHS / United States R01 HL071194 / HL / NHLBI NIH HHS / United States U01 HL080295 / HL / NHLBI NIH HHS / United States R01 HL070847 / HL / NHLBI NIH HHS / United States U01 HL096917 / HL / NHLBI NIH HHS / United States HHSN268201500001C / HL / NHLBI NIH HHS / United States R01 HL146339 / HL / NHLBI NIH HHS / United States R01 AG062531 / AG / NIA NIH HHS / United States R01 AR035583 / AR / NIAMS NIH HHS / United States U01 HL130114 / HL / NHLBI NIH HHS / United States HHSN268200800007C / HL / NHLBI NIH HHS / United States R01 AG026720 / AG / NIA NIH HHS / United States R01 AR035584 / AR / NIAMS NIH HHS / United States R01 AG070867 / AG / NIA NIH HHS / United States U01 HL096902 / HL / NHLBI NIH HHS / United States R01 HL070842 / HL / NHLBI NIH HHS / United States U01 AG042124 / AG / NIA NIH HHS / United States N01HC55222 / HL / NHLBI NIH HHS / United States U01 AG042145 / AG / NIA NIH HHS / United States R01 AG049607 / AG / NIA NIH HHS / United States R01 AG027576 / AG / NIA NIH HHS / United States N01HC85086 / HL / NHLBI NIH HHS / United States R01 HL105756 / HL / NHLBI NIH HHS / United States U01 HL064360 / HL / NHLBI NIH HHS / United States R01 AG005407 / AG / NIA NIH HHS / United States R01 AG066524 / AG / NIA NIH HHS / United States HHSN268201200036C / HL / NHLBI NIH HHS / United States K24 HL159246 / HL / NHLBI NIH HHS / United States HHSN268201800001C / HL / NHLBI NIH HHS / United States HHSN268201500001I / HL / NHLBI NIH HHS / United States R01 HL070841 / HL / NHLBI NIH HHS / United States U01 AG042140 / AG / NIA NIH HHS / United States U01 HL096814 / HL / NHLBI NIH HHS / United States R01 HL070838 / HL / NHLBI NIH HHS / United States P30 AG066546 / AG / NIA NIH HHS / United States 75N92022D00003 / HL / NHLBI NIH HHS / United States U01 HL053934 / HL / NHLBI NIH HHS / United States 75N92021D00006 / HL / NHLBI NIH HHS / United States 75N92022D00005 / HL / NHLBI NIH HHS / United States N01HC85082 / HL / NHLBI NIH HHS / United States N01HC85083 / HL / NHLBI NIH HHS / United States N01HC25195 / HL / NHLBI NIH HHS / United States R35 AG071916 / AG / NIA NIH HHS / United States 75N92019D00031 / HL / NHLBI NIH HHS / United States U01 HL096899 / HL / NHLBI NIH HHS / United States R01 AR035582 / AR / NIAMS NIH HHS / United States U01 AG027810 / AG / NIA NIH HHS / United States R01 AG005394 / AG / NIA NIH HHS / United States N01HC85079 / HL / NHLBI NIH HHS / United States R01 AG023629 / AG / NIA NIH HHS / United States R01 HL070837 / HL / NHLBI NIH HHS / United States 75N92022D00001 / HL / NHLBI NIH HHS / United States U01 AG042143 / AG / NIA NIH HHS / United States U01 AG042139 / AG / NIA NIH HHS / United States R01 AG027574 / AG / NIA NIH HHS / United States U01 AR066160 / AR / NIAMS NIH HHS / United States N01HC85081 / HL / NHLBI NIH HHS / United States |
ePub date:
24/11