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Human Plasma Proteomic Profile of Clonal Hematopoiesis.
Tuesday,2025-02-11 15:07 America/Los_Angeles — ecterry
| Title | Human Plasma Proteomic Profile of Clonal Hematopoiesis. |
| Publication Type | Journal Article |
| Year of Publication | 2024 |
| Authors | Yu, Z, Vromman, A, Nguyen, NQuynh H, Schuermans, A, Rentz, T, Vellarikkal, SK, Uddin, MMesbah, Niroula, A, Griffin, G, Honigberg, MC, Lin, AE, Gibson, CJ, Katz, DH, Tahir, U, Fang, S, Haidermota, S, Ganesh, S, Antoine, T, Weinstock, J, Austin, TR, Ramachandran, VS, Peloso, GM, Hornsby, W, Ganz, P, Manson, JAE, Haring, B, Kooperberg, CL, Reiner, AP, Bis, JC, Psaty, BM, Min, Y-I, Correa, A, Lange, LA, Post, WS, Rotter, JI, Rich, SS, Wilson, JG, Ebert, BL, Yu, B, Ballantyne, CM, Coresh, J, Sankaran, VG, Bick, AG, Jaiswal, S, Gerszten, RE, Libby, P, Gupta, RM, Natarajan, P |
| Corporate/Institutional Authors | NHLBI Trans-Omics for Precision Medicine |
| Journal | bioRxiv |
| Date Published | 2024 Oct 31 |
| ISSN | 2692-8205 |
| Abstract | <p>Plasma proteomic profiles associated with subclinical somatic mutations in blood cells may offer novel insights into downstream clinical consequences. Here, we explore such patterns in clonal hematopoiesis of indeterminate potential (CHIP), which is linked to several cancer and non-cancer outcomes, including coronary artery disease (CAD). Among 61,833 ancestrally diverse participants (3,881 with CHIP) from NHLBI TOPMed and UK Biobank with blood-based DNA sequencing and proteomic measurements (1,148 proteins by SomaScan in TOPMed and 2,917 proteins by Olink in UK Biobank), we identified 32 and 345 unique proteins from TOPMed and UK Biobank, respectively, associated with the most prevalent driver genes (, , and ). These associations showed substantial heterogeneity by driver genes, sex, and race, and were enriched for immune response and inflammation pathways. Mendelian randomization in humans, coupled with ELISA in hematopoietic -/- vs wild-type mice validation, disentangled causal proteomic perturbations from CHIP. Lastly, we identified plasma proteins shared between CHIP and CAD.</p> |
| DOI | 10.1101/2023.07.25.550557 |
| Alternate Journal | bioRxiv |
| PubMed ID | 39554199 |
| PubMed Central ID | PMC11565774 |
| Grant List | RC2 HL102419 / HL / NHLBI NIH HHS / United States R01 HL148565 / HL / NHLBI NIH HHS / United States R01 HL134892 / HL / NHLBI NIH HHS / United States R01 HL127564 / HL / NHLBI NIH HHS / United States P30 DK063491 / DK / NIDDK NIH HHS / United States UL1 TR000040 / TR / NCATS NIH HHS / United States HHSN268201800010I / HB / NHLBI NIH HHS / United States N01HC85081 / HL / NHLBI NIH HHS / United States 75N92020D00002 / HL / NHLBI NIH HHS / United States HHSN268201500003C / HL / NHLBI NIH HHS / United States HHSN268201800012C / HL / NHLBI NIH HHS / United States 75N92020D00005 / HL / NHLBI NIH HHS / United States N01HC95160 / HL / NHLBI NIH HHS / United States DP5 OD029586 / OD / NIH HHS / United States R01 HL120393 / HL / NHLBI NIH HHS / United States U54 HG003067 / HG / NHGRI NIH HHS / United States U01 DK108809 / DK / NIDDK NIH HHS / United States HHSN268201600002C / HL / NHLBI NIH HHS / United States R01 MH104964 / MH / NIMH NIH HHS / United States 75N92022D00002 / HL / NHLBI NIH HHS / United States R01 HL153499 / HL / NHLBI NIH HHS / United States R01 HL151283 / HL / NHLBI NIH HHS / United States N01HC95163 / HL / NHLBI NIH HHS / United States U01 HL080295 / HL / NHLBI NIH HHS / United States R01 HL163099 / HL / NHLBI NIH HHS / United States UL1 TR001079 / TR / NCATS NIH HHS / United States HHSN268201600018C / HL / NHLBI NIH HHS / United States HHSN268201800014I / HB / NHLBI NIH HHS / United States R01 DK125782 / DK / NIDDK NIH HHS / United States U01 HL130114 / HL / NHLBI NIH HHS / United States HHSN268200800007C / HL / NHLBI NIH HHS / United States 75N92020D00001 / HL / NHLBI NIH HHS / United States N01HC95169 / HL / NHLBI NIH HHS / United States U01 HG004402 / HG / NHGRI NIH HHS / United States N01HC95164 / HL / NHLBI NIH HHS / United States N01HC55222 / HL / NHLBI NIH HHS / United States HHSN268201800014C / HL / NHLBI NIH HHS / United States N01HC95162 / HL / NHLBI NIH HHS / United States N01HC85086 / HL / NHLBI NIH HHS / United States 75N92020D00003 / HL / NHLBI NIH HHS / United States R01 HL105756 / HL / NHLBI NIH HHS / United States N01HC95168 / HL / NHLBI NIH HHS / United States 75N92022D00004 / HL / NHLBI NIH HHS / United States R01 HL142711 / HL / NHLBI NIH HHS / United States HHSN268201200036C / HL / NHLBI NIH HHS / United States HHSN268201800001C / HL / NHLBI NIH HHS / United States HHSN268201800013I / MD / NIMHD NIH HHS / United States R01 HL151152 / HL / NHLBI NIH HHS / United States HHSN268201600003C / HL / NHLBI NIH HHS / United States R01 HL159081 / HL / NHLBI NIH HHS / United States N01HC95165 / HL / NHLBI NIH HHS / United States N01HC95159 / HL / NHLBI NIH HHS / United States HHSN268201800012I / HL / NHLBI NIH HHS / United States N01HC95161 / HL / NHLBI NIH HHS / United States UL1 TR001420 / TR / NCATS NIH HHS / United States 75N92020D00004 / HL / NHLBI NIH HHS / United States HHSN268201600004C / HL / NHLBI NIH HHS / United States DP2 HL157540 / HL / NHLBI NIH HHS / United States HHSN268201800011C / HL / NHLBI NIH HHS / United States 75N92020D00007 / HL / NHLBI NIH HHS / United States R01 MH123451 / MH / NIMH NIH HHS / United States HHSN268201600001C / HL / NHLBI NIH HHS / United States 75N92022D00003 / HL / NHLBI NIH HHS / United States HHSN268201500003I / HL / NHLBI NIH HHS / United States 75N92021D00006 / HL / NHLBI NIH HHS / United States 75N92022D00005 / HL / NHLBI NIH HHS / United States N01HC85082 / HL / NHLBI NIH HHS / United States N01HC95167 / HL / NHLBI NIH HHS / United States N01HC85083 / HL / NHLBI NIH HHS / United States HHSN268201800015I / HB / NHLBI NIH HHS / United States R01 HL117626 / HL / NHLBI NIH HHS / United States 75N92020D00006 / HL / NHLBI NIH HHS / United States N01HC85079 / HL / NHLBI NIH HHS / United States N01HC95166 / HL / NHLBI NIH HHS / United States R01 HL135242 / HL / NHLBI NIH HHS / United States R01 AG023629 / AG / NIA NIH HHS / United States UL1 TR001881 / TR / NCATS NIH HHS / United States HHSN268201800011I / HB / NHLBI NIH HHS / United States R01 HL134320 / HL / NHLBI NIH HHS / United States N01HC85080 / HL / NHLBI NIH HHS / United States 75N92022D00001 / HL / NHLBI NIH HHS / United States R01 HL148050 / HL / NHLBI NIH HHS / United States T32 HL007604 / HL / NHLBI NIH HHS / United States |
ePub date:
24/10