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A large-scale genome-wide study of gene-sleep duration interactions for blood pressure in 811,405 individuals from diverse populations.
Tuesday,2025-04-08 13:57 America/Los_Angeles — ecterry
| Title | A large-scale genome-wide study of gene-sleep duration interactions for blood pressure in 811,405 individuals from diverse populations. |
| Publication Type | Journal Article |
| Year of Publication | 2025 |
| Authors | Nagarajan, P, Winkler, TW, Bentley, AR, Miller, CL, Kraja, AT, Schwander, K, Lee, S, Wang, W, Brown, MR, Morrison, JL, Giri, A, O'Connell, JR, Bartz, TM, Fuentes, Lde Las, Gudmundsdottir, V, Guo, X, Harris, SE, Huang, Z, Kals, M, Kho, M, Lefevre, C, Luan, J'an, Lyytikäinen, L-P, Mangino, M, Milaneschi, Y, Palmer, ND, Rao, V, Rauramaa, R, Shen, B, Stadler, S, Sun, Q, Tang, J, Thériault, S, van der Graaf, A, van der Most, PJ, Wang, Y, Weiss, S, Westerman, KE, Yang, Q, Yasuharu, T, Zhao, W, Zhu, W, Altschul, D, Ansari, MAbu Yusuf, Anugu, P, Argoty-Pantoja, AD, Arzt, M, Aschard, H, Attia, JR, Bazzanno, L, Breyer, MA, Brody, JA, Cade, BE, Chen, H-H, Chen, Y-DI, Chen, Z, de Vries, PS, Dimitrov, LM, Do, A, Du, J, Dupont, CT, Edwards, TL, Evans, MK, Faquih, T, Felix, SB, Fisher-Hoch, SP, Floyd, JS, Graff, M, Gu, C, Gu, D, Hairston, KG, Hanley, AJ, Heid, IM, Heikkinen, S, Highland, HM, Hood, MM, Kähönen, M, Karvonen-Gutierrez, CA, Kawaguchi, T, Kazuya, S, Kelly, TN, Komulainen, P, Levy, D, Lin, HJ, Liu, PY, Marques-Vidal, P, McCormick, JB, Mei, H, Meigs, JB, Menni, C, Nam, K, Nolte, IM, Pacheco, NL, Petty, LE, Polikowsky, HG, Province, MA, Psaty, BM, Raffield, LM, Raitakari, OT, Rich, SS, Riha, RL, Risch, L, Risch, M, Ruiz-Narvaez, EA, Scott, RJ, Sitlani, CM, Smith, JA, Sofer, T, Teder-Laving, M, Völker, U, Vollenweider, P, Wang, G, van Dijk, KWillems, Wilson, OD, Xia, R, Yao, J, Young, KL, Zhang, R, Zhu, X, Below, JE, Böger, CA, Conen, D, Cox, SR, Dörr, M, Feitosa, MF, Fox, ER, Franceschini, N, Gharib, SA, Gudnason, V, Harlow, SD, He, J, Holliday, EG, Kutalik, Z, Lakka, TA, Lawlor, DA, Lee, S, Lehtimäki, T, Li, C, Liu, C-T, Mägi, R, Matsuda, F, Morrison, AC, Penninx, BWjh, Peyser, PA, Rotter, JI, Snieder, H, Spector, TD, Wagenknecht, LE, Wareham, NJ, Zonderman, AB, North, KE, Fornage, M, Hung, AM, Manning, AK, Gauderman, J, Chen, H, Munroe, PB, Rao, DC, van Heemst, D, Redline, S, Noordam, R, Wang, H |
| Corporate/Institutional Authors | Million Veteran Program |
| Journal | Mol Psychiatry |
| Date Published | 2025 Apr 04 |
| ISSN | 1476-5578 |
| Abstract | <p>Although both short and long sleep duration are associated with elevated hypertension risk, our understanding of their interplay with biological pathways governing blood pressure remains limited. To address this, we carried out genome-wide cross-population gene-by-short-sleep and long-sleep duration interaction analyses for three blood pressure traits (systolic, diastolic, and pulse pressure) in 811,405 individuals from diverse population groups. We discovered 22 novel gene-sleep duration interaction loci for blood pressure, mapped to 23 genes. Investigating these genes' functional implications shed light on neurological, thyroidal, bone metabolism, and hematopoietic pathways that necessitate future investigation for blood pressure management that caters to sleep health lifestyle. Non-overlap between short sleep (12) and long sleep (10) interactions underscores the plausible nature of distinct influences of both sleep duration extremes in cardiovascular health. Several of our loci are specific towards a particular population background or sex, emphasizing the importance of addressing heterogeneity entangled in gene-environment interactions, when considering precision medicine design approaches for blood pressure management.</p> |
| DOI | 10.1038/s41380-025-02954-w |
| Alternate Journal | Mol Psychiatry |
| PubMed ID | 40181193 |
| PubMed Central ID | 10239254 |
| Grant List | R01HL118305 / / U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) / R01HL156991 / / U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) / CX001897 / / U.S. Department of Veterans Affairs (Department of Veterans Affairs) / |
ePub date:
25/04