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Plasma TAR DNA-binding protein 43 (TDP-43) levels in a population-based cohort of older adults: The cardiovascular health study.
Wednesday,2025-05-14 14:25 America/Los_Angeles — ecterry
| Title | Plasma TAR DNA-binding protein 43 (TDP-43) levels in a population-based cohort of older adults: The cardiovascular health study. |
| Publication Type | Journal Article |
| Year of Publication | 2025 |
| Authors | Fohner, AE, Sitlani, CM, Jayadev, S, Bis, JC, Trittschuh, EH, Lopez, OL, Tracy, RP, Psaty, BM, Longstreth, WT, Seshadri, S |
| Journal | J Alzheimers Dis |
| Pagination | 13872877251334820 |
| Date Published | 2025 Apr 23 |
| ISSN | 1875-8908 |
| Abstract | <p>Brain deposition of transactive response DNA-binding protein 43 (TDP-43) is a feature of neurodegenerative syndromes. We evaluated TDP-43 plasma concentrations in 1058 participants in the Cardiovascular Health Study (CHS), a population-based longitudinal cohort. The cohort was 38% male, 11% Black, had a mean age 75 years, and 261 people developed dementia over a mean of 5.5 years of follow up. Median TDP-43 levels were 211.0 pg/mL (IQR: 134.0-341.0 pg/mL). TDP-43 levels were not associated with cross-sectional or longitudinal change in cognitive scores, with plasma AD biomarkers, with brain MRI volumes, with incident dementia, or with demographic characteristics.</p> |
| DOI | 10.1177/13872877251334820 |
| Alternate Journal | J Alzheimers Dis |
| PubMed ID | 40267298 |
ePub date:
25/04