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Association of Immune Cell Subsets With Longevity: The Cardiovascular Health Study.
Wednesday,2025-07-16 10:55 America/Los_Angeles — ecterry
| Title | Association of Immune Cell Subsets With Longevity: The Cardiovascular Health Study. |
| Publication Type | Journal Article |
| Year of Publication | 2025 |
| Authors | Lai, SDobrota, Bůzková, P, Delaney, JA, Olson, NC, Psaty, BM, Huber, SA, Doyle, MF, Tracy, RP, Odden, MC |
| Journal | J Gerontol A Biol Sci Med Sci |
| Volume | 80 |
| Issue | 7 |
| Date Published | 2025 Jun 10 |
| ISSN | 1758-535X |
| Keywords | Aged, Aged, 80 and over, Aging, Cardiovascular Diseases, CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, Female, Humans, Killer Cells, Natural, Longevity, Male |
| Abstract | <p><b>BACKGROUND: </b>Changes in the immune system are a potential biological mechanism of aging. We investigated the association of circulating immune cell subsets with age at death and survival to age 90.</p><p><b>METHODS: </b>Immune cell phenotypes were measured at baseline in 1 625 adults, aged 70-85 years, in the Cardiovascular Health Study. We selected 5 primary immune cell subsets: gamma-delta T-cells, natural killer cells, CD8+ T effector memory CD45RA expressing cells(TEMRA) cells, ratio of CD4+ to CD8+ cells, and ratio of naïve to memory CD8+ cells. We used linear regression and Poisson models, adjusting for demographics and clinical factors; and tested for effect modification by sex and race. In a secondary analysis, we investigated 23 additional immune cell subsets, using the Holm-Bonferroni method to adjust for multiple comparisons.</p><p><b>RESULTS: </b>No primary immune cell subsets were significantly associated with longevity. Two secondary subsets were significantly associated with age at death. Each SD higher proportion of CD4+CD57+ cells was associated with a 0.64-year earlier death (95% CI: -0.99, -0.30) and each SD higher proportion of CD4+CD28-CD57+ cells was associated with a 0.54-year earlier death (95% CI: -0.87, -0.21). Several subsets had significant interactions with sex and race in the fully adjusted model of age at death. A higher proportion of CD4+CD57+ T-cells was significantly associated with lower likelihood of survival to age 90 (relative risk: 0.79) and 1.07-year earlier age at death in males, but not in females.</p><p><b>CONCLUSIONS: </b>Our results suggest that CD4+CD57+ cells are associated with earlier death and this relationship was stronger in males than females.</p> |
| DOI | 10.1093/gerona/glaf094 |
| Alternate Journal | J Gerontol A Biol Sci Med Sci |
| PubMed ID | 40378276 |
| PubMed Central ID | PMC12159800 |
| Grant List | N01HC85081 / HL / NHLBI NIH HHS / United States U01 HL130114 / HL / NHLBI NIH HHS / United States N01HC55222 / HL / NHLBI NIH HHS / United States R01AG023629 / NS / NINDS NIH HHS / United States 75N92021D00006 / HL / NHLBI NIH HHS / United States U01HL130114 / HL / NHLBI NIH HHS / United States HHSN268201800001C / HL / NHLBI NIH HHS / United States N01 HC085081 / HL / NHLBI NIH HHS / United States N01 HC085080 / HL / NHLBI NIH HHS / United States U01HL080295 / HL / NHLBI NIH HHS / United States N01HC85083 / HL / NHLBI NIH HHS / United States U01 HL080295 / HL / NHLBI NIH HHS / United States N01 HC085082 / HL / NHLBI NIH HHS / United States R01HL172803 / HL / NHLBI NIH HHS / United States N01 HC085086 / HL / NHLBI NIH HHS / United States N01 HC085083 / HL / NHLBI NIH HHS / United States N01HC85082 / HL / NHLBI NIH HHS / United States R01HL135625 / HL / NHLBI NIH HHS / United States R01 HL120854 / HL / NHLBI NIH HHS / United States R01 HL135625 / HL / NHLBI NIH HHS / United States N01 HC055222 / HL / NHLBI NIH HHS / United States HHSN268201200036C / HL / NHLBI NIH HHS / United States R01HL120854 / HL / NHLBI NIH HHS / United States N01 HC085079 / HL / NHLBI NIH HHS / United States HHSN268200800007C / HL / NHLBI NIH HHS / United States R01 HL172803 / HL / NHLBI NIH HHS / United States N01HC85080 / HL / NHLBI NIH HHS / United States R01 AG023629 / AG / NIA NIH HHS / United States N01HC85086 / HL / NHLBI NIH HHS / United States N01HC85079 / HL / NHLBI NIH HHS / United States |
ePub date:
25/06