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... diabetes beta-cell abdominal obesity Background: Understanding the underlying putative defects leading to the ... of type 2 diabetes has been a challenging feat. In healthy individuals, glucose tolerance is maintained in ... it appears that elevation in glucose and eventually lipids compromise the beta-cells’ ability to compensate by ...- 2016-08-15 17:41 - 4 comments
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... 1000 genomes imputation Introduction [Rationale and background]: Meta-analyses of genome wide association studies (GWAS) of Type 2 diabetes and diabetes-related quantitative traits (QT) have had a revolutionary impact on our understanding of genetic contributions to diabetes susceptibility ...- 2013-12-09 14:17 - 1 comment
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... retinopathy (DR) using a large, multiethnic dataset and liability threshold modeling of duration of diabetes and glycemic control to increase study’s power. The ... with the discovery results. We also applied the Disease Association Protein-Protein Link Evaluator (DAPPLE) ...- 2018-01-22 11:25
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... is a condition in which the cornea progressively thins and protrudes, losing its natural shape. It is a major cause ... association study (GWAS) followed by replication and meta-analysis. Subjects : The discovery cohort comprised 522 Australian keratoconus cases and 2036 Australian controls. Controls were drawn from the ...- 2018-07-30 14:19
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... retinal microvascular diameters are associated with cardio- and cerebrovascular conditions. However, our understanding of the genetic factors that mediate retinal vessel ... the relationship between retinal and systemic microvascular disease. exome chip Central retinal arteriolar equivalent ...- 2015-04-27 16:56 - 1 comment
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Identification of coding variant associations for complex diseases offers a direct route to biological insight, but is ... those variants on disease risk. We aggregated exome-array and exome sequencing data for 81,412 type 2 diabetes (T2D) cases and 370,832 controls of diverse ancestry, identifying 40 ...- 2017-05-01 14:24
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... genotyping technology have made possible the query of thousands to millions of single nucleotide variants (SNVs) for ... genetic variants have a small effect on complex traits, and detection of association is only possible with large ... method of choice to combine results from multiple studies and improve power to detect associated variants in genome ...- 2015-04-20 13:18 - 1 comment