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... and mineral-metabolism pathways, in relation to incident moderate or severe AS (primary outcome) and clinically ... Of 5,390 participants (age 72.9 [5.6] years), 287 developed moderate or severe AS, and 175 clinically significant AS, ... (HR=1.16 per SD [1.01, 1.34]) were associated with incident moderate or severe AS, while Black race demonstrated an ...- 2020-06-24 09:36 - 2 comments
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... was examined using multivariable Cox proportional hazards models. Results: During a mean follow-up of 8.4 years, 439 ... measures of myocardial stress, dysfunction, and remodeling did not meaningfully alter these associations. ... of clinical and laboratory covariates. Subsequent models will examine the extent to which this is independent ...- 2018-09-30 18:23
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... was examined using multivariable Cox proportional hazards models. Results: OC and CTX were strongly correlated ... a metabolically active hormone, whose abrogation in animal models leads to diabetes. 1 In clinical studies, OC has ... disease (CVD) and reduced life expectancy in the modern era. 13 Given the marked incidence and prevalence ...- 2017-09-28 13:20 - 1 comment
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... AVC with stenosis in men, as well as femoral neck BMD with moderate/severe MAC in women. These findings will require ... exhibits such features as bone formation and remodeling 8 , and has been linked to Vitamin D receptor ... and cardiac calcification in particular. In animal models, anti-resorptive therapy with bisphosphonates has ...- 2015-04-08 18:30 - 2 comments
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... direct information on underlying processes driving bone remodeling. Therefore, they may allow both earlier ... can provide information on both components of the bone remodeling process. Among existing BTMs, two leading ... levels (per SD increment). Cox proportional hazard models will be used to evaluate the associations of OC and ...- 2017-09-28 13:28 - 1 comment
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... resorption, with the risk of incident clinically important (moderate and severe) aortic stenosis in older women. The ... approved 12/22/2016 Outcome: Incident clinically important (moderate and severe) aortic stenosis in older adults; in an ... is being undertaken to ascertain cases of incident moderate or severe AS. Standard definitions based on peak ...- 2017-09-28 13:35 - 1 comment